Identification of urinary metabolites of (±)-2-(p-isobutylphenyl)propionic acid (Ibuprofen) by routine organic acid screening

Michael J. Bennett, W. Geoffrey Sherwood, Ajay Bhala, Daniel E. Hale

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Ibuprofen [(±)-2-(p-isobutylphenyl)propionic acid] has recently been introduced as a pediatric anti-inflammatory agent. To determine how this agent interferes with urine organic acid analysis, an important pediatric investigation, we have analyzed urine from two subjects pre- and post-Ibuprofen dosage and two subjects on chronic Ibuprofen therapy. A distinctive pattern of drug interference on the organic acid profile was detected. There were three major components, corresponding to unmetabolized Ibuprofen and to the oxidation products hydroxy Ibuprofen and carboxy Ibuprofen. Therefore, the major mechanism of Ibuprofen metabolism appears to be microsomal, although mitochondrial and peroxisomal routes cannot be excluded. Laboratories carrying out routine organic acid analysis should be aware of the nature and magnitude of the organic aciduria caused by Ibuprofen.

Original languageEnglish (US)
Pages (from-to)55-62
Number of pages8
JournalClinica Chimica Acta
Volume210
Issue number1-2
DOIs
StatePublished - Sep 15 1992
Externally publishedYes

Fingerprint

Ibuprofen
Organic acids
Metabolites
Screening
Acids
Pediatrics
Urine
propionic acid
Metabolism
Anti-Inflammatory Agents
Oxidation

Keywords

  • Drug interference with laboratory testing
  • Ibuprofen
  • Screening for metabolic diseases

ASJC Scopus subject areas

  • Biochemistry
  • Clinical Biochemistry

Cite this

Identification of urinary metabolites of (±)-2-(p-isobutylphenyl)propionic acid (Ibuprofen) by routine organic acid screening. / Bennett, Michael J.; Sherwood, W. Geoffrey; Bhala, Ajay; Hale, Daniel E.

In: Clinica Chimica Acta, Vol. 210, No. 1-2, 15.09.1992, p. 55-62.

Research output: Contribution to journalArticle

Bennett, Michael J. ; Sherwood, W. Geoffrey ; Bhala, Ajay ; Hale, Daniel E. / Identification of urinary metabolites of (±)-2-(p-isobutylphenyl)propionic acid (Ibuprofen) by routine organic acid screening. In: Clinica Chimica Acta. 1992 ; Vol. 210, No. 1-2. pp. 55-62.
@article{6263fb29727e4377a58b93acf47e66d5,
title = "Identification of urinary metabolites of (±)-2-(p-isobutylphenyl)propionic acid (Ibuprofen) by routine organic acid screening",
abstract = "Ibuprofen [(±)-2-(p-isobutylphenyl)propionic acid] has recently been introduced as a pediatric anti-inflammatory agent. To determine how this agent interferes with urine organic acid analysis, an important pediatric investigation, we have analyzed urine from two subjects pre- and post-Ibuprofen dosage and two subjects on chronic Ibuprofen therapy. A distinctive pattern of drug interference on the organic acid profile was detected. There were three major components, corresponding to unmetabolized Ibuprofen and to the oxidation products hydroxy Ibuprofen and carboxy Ibuprofen. Therefore, the major mechanism of Ibuprofen metabolism appears to be microsomal, although mitochondrial and peroxisomal routes cannot be excluded. Laboratories carrying out routine organic acid analysis should be aware of the nature and magnitude of the organic aciduria caused by Ibuprofen.",
keywords = "Drug interference with laboratory testing, Ibuprofen, Screening for metabolic diseases",
author = "Bennett, {Michael J.} and Sherwood, {W. Geoffrey} and Ajay Bhala and Hale, {Daniel E.}",
year = "1992",
month = "9",
day = "15",
doi = "10.1016/0009-8981(92)90045-R",
language = "English (US)",
volume = "210",
pages = "55--62",
journal = "Clinica Chimica Acta",
issn = "0009-8981",
publisher = "Elsevier",
number = "1-2",

}

TY - JOUR

T1 - Identification of urinary metabolites of (±)-2-(p-isobutylphenyl)propionic acid (Ibuprofen) by routine organic acid screening

AU - Bennett, Michael J.

AU - Sherwood, W. Geoffrey

AU - Bhala, Ajay

AU - Hale, Daniel E.

PY - 1992/9/15

Y1 - 1992/9/15

N2 - Ibuprofen [(±)-2-(p-isobutylphenyl)propionic acid] has recently been introduced as a pediatric anti-inflammatory agent. To determine how this agent interferes with urine organic acid analysis, an important pediatric investigation, we have analyzed urine from two subjects pre- and post-Ibuprofen dosage and two subjects on chronic Ibuprofen therapy. A distinctive pattern of drug interference on the organic acid profile was detected. There were three major components, corresponding to unmetabolized Ibuprofen and to the oxidation products hydroxy Ibuprofen and carboxy Ibuprofen. Therefore, the major mechanism of Ibuprofen metabolism appears to be microsomal, although mitochondrial and peroxisomal routes cannot be excluded. Laboratories carrying out routine organic acid analysis should be aware of the nature and magnitude of the organic aciduria caused by Ibuprofen.

AB - Ibuprofen [(±)-2-(p-isobutylphenyl)propionic acid] has recently been introduced as a pediatric anti-inflammatory agent. To determine how this agent interferes with urine organic acid analysis, an important pediatric investigation, we have analyzed urine from two subjects pre- and post-Ibuprofen dosage and two subjects on chronic Ibuprofen therapy. A distinctive pattern of drug interference on the organic acid profile was detected. There were three major components, corresponding to unmetabolized Ibuprofen and to the oxidation products hydroxy Ibuprofen and carboxy Ibuprofen. Therefore, the major mechanism of Ibuprofen metabolism appears to be microsomal, although mitochondrial and peroxisomal routes cannot be excluded. Laboratories carrying out routine organic acid analysis should be aware of the nature and magnitude of the organic aciduria caused by Ibuprofen.

KW - Drug interference with laboratory testing

KW - Ibuprofen

KW - Screening for metabolic diseases

UR - http://www.scopus.com/inward/record.url?scp=0026785765&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0026785765&partnerID=8YFLogxK

U2 - 10.1016/0009-8981(92)90045-R

DO - 10.1016/0009-8981(92)90045-R

M3 - Article

C2 - 1424159

AN - SCOPUS:0026785765

VL - 210

SP - 55

EP - 62

JO - Clinica Chimica Acta

JF - Clinica Chimica Acta

SN - 0009-8981

IS - 1-2

ER -