Identification of the 64K autoantigen in insulin-dependent diabetes as the GABA-synthesizing enzyme glutamic acid decarboxylase

Steinunn Baekkeskov; Henk Jan Aanstoot; Stephan Christgai; Annette Reetz; Michele Solimena; Marilia Cascalho; Franco Folli; Hanne Richter-Olesen; Pietro De Camilli

doi:10.1038/347151a0

Identification of the 64K autoantigen in insulin-dependent diabetes as the GABA-synthesizing enzyme glutamic acid decarboxylase

Steinunn Baekkeskov, Henk Jan Aanstoot, Stephan Christgai, Annette Reetz, Michele Solimena, Marilia Cascalho, Franco Folli, Hanne Richter-Olesen, Pietro De Camilli

Medicine

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Abstract

The pancreatic islet β-cell autoantigen of relative molecular mass 64,000 (64K), which is a major target of autoantibodies associated with the development of insulin-dependent diabetes mel-litus (IDDM) has been identified as glutamic acid decarboxylase, the biosynthesizing enzyme of the inhibitory neurotransmitter GABA (γ-aminobutyric acid). Pancreatic β cells and a subpopulation of central nervous system neurons express high levels of this enzyme. Autoantibodies against glutamic acid decarboxylase with a higher titre and increased epitope recognition compared with those usually associated with IDDM are found in stiff-man syndrome, a rare neurological disorder characterized by a high coincidence with IDDM.

Original language	English (US)
Pages (from-to)	151-156
Number of pages	6
Journal	Nature
Volume	347
Issue number	6289
DOIs	https://doi.org/10.1038/347151a0
State	Published - 1990

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Identification of the 64K autoantigen in insulin-dependent diabetes as the GABA-synthesizing enzyme glutamic acid decarboxylase. / Baekkeskov, Steinunn; Aanstoot, Henk Jan; Christgai, Stephan; Reetz, Annette; Solimena, Michele; Cascalho, Marilia; Folli, Franco; Richter-Olesen, Hanne; Camilli, Pietro De.

In: Nature, Vol. 347, No. 6289, 1990, p. 151-156.

Research output: Contribution to journal › Article › peer-review

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abstract = "The pancreatic islet β-cell autoantigen of relative molecular mass 64,000 (64K), which is a major target of autoantibodies associated with the development of insulin-dependent diabetes mel-litus (IDDM) has been identified as glutamic acid decarboxylase, the biosynthesizing enzyme of the inhibitory neurotransmitter GABA (γ-aminobutyric acid). Pancreatic β cells and a subpopulation of central nervous system neurons express high levels of this enzyme. Autoantibodies against glutamic acid decarboxylase with a higher titre and increased epitope recognition compared with those usually associated with IDDM are found in stiff-man syndrome, a rare neurological disorder characterized by a high coincidence with IDDM.",

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AU - Solimena, Michele

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AU - Folli, Franco

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Identification of the 64K autoantigen in insulin-dependent diabetes as the GABA-synthesizing enzyme glutamic acid decarboxylase

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