Identification of the 64K autoantigen in insulin-dependent diabetes as the GABA-synthesizing enzyme glutamic acid decarboxylase

Steinunn Baekkeskov, Henk Jan Aanstoot, Stephan Christgai, Annette Reetz, Michele Solimena, Marilia Cascalho, Franco Folli, Hanne Richter-Olesen, Pietro De Camilli

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Abstract

The pancreatic islet β-cell autoantigen of relative molecular mass 64,000 (64K), which is a major target of autoantibodies associated with the development of insulin-dependent diabetes mel-litus (IDDM) has been identified as glutamic acid decarboxylase, the biosynthesizing enzyme of the inhibitory neurotransmitter GABA (γ-aminobutyric acid). Pancreatic β cells and a subpopulation of central nervous system neurons express high levels of this enzyme. Autoantibodies against glutamic acid decarboxylase with a higher titre and increased epitope recognition compared with those usually associated with IDDM are found in stiff-man syndrome, a rare neurological disorder characterized by a high coincidence with IDDM.

Original languageEnglish (US)
Pages (from-to)151-156
Number of pages6
JournalNature
Volume347
Issue number6289
DOIs
StatePublished - 1990

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    Baekkeskov, S., Aanstoot, H. J., Christgai, S., Reetz, A., Solimena, M., Cascalho, M., Folli, F., Richter-Olesen, H., & Camilli, P. D. (1990). Identification of the 64K autoantigen in insulin-dependent diabetes as the GABA-synthesizing enzyme glutamic acid decarboxylase. Nature, 347(6289), 151-156. https://doi.org/10.1038/347151a0