Identification of perfusion abnormalities using FSO69, a novel contrast agent, in conscious dogs

Sameh Mobarek, Marc Kates, Mario Meza, Carlos Moreno, Susan Revall, Wayne Barbee, Joseph P. Murgo, Jorge Cheirif

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

Recent advances in the production of echocardiographic contrast agents has resulted in the ability to delineate areas of hypoperfusion after coronary occlusions and stenoses following their intravenous injection. Most of these studies though have been done in open chest animals. This study was done to determine if we could assess myocardial perfusion following the intravenous administration of FS069, a suspension of perfluoropropane filled albumin microspheres (3.6 μm average microbubble size, concentration 8 x 108), in spontaneously breathing closed chest dogs. Twenty-seven mongrel dogs were instrumented on day 1. The chest was then closed and the dogs were restudied 3-7 days later, while spontaneously breathing. Homogeneous perfusion was observed in most dogs by all three independent and blinded observers. Perfusion abnormalities were likewise identified in most instances by all blinded reviewers on interventions designed to decrease regional blood flow. A good correlation between perfusion defect size between investigators was observed. In summary, our data suggest that FS069 can be used to assess regional myocardial perfusion in spontaneously breathing dogs. These results support its use in humans.

Original languageEnglish (US)
Pages (from-to)337-344
Number of pages8
JournalEchocardiography
Volume14
Issue number4
DOIs
StatePublished - Jan 1 1997
Externally publishedYes

Keywords

  • Echocardiographic contrast agents
  • Myocardial contrast echocardiography
  • Myocardial perfusion

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Cardiology and Cardiovascular Medicine

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