Identification of Mycoplasma pneumoniae proteins associated with hemadsorption and virulence

D. C. Krause, D. K. Leith, R. M. Wilson, J. B. Baseman

Research output: Contribution to journalArticle

131 Scopus citations

Abstract

Twenty-two mutants of Mycoplasma pneumoniae spontaneously deficient in hemadsorption were isolated. Examination of mutant protein profiles by one- and two-dimensional polyacrylamide gel electrophoresis permitted the grouping of these mutants into four classes. The largest class of mutants was deficient in four high-molecular-weight proteins (215,000, 210,000, 190,000, and 140,000). A second class of mutants lacked three proteins previously designated A, B, and C (72,00, 85,000, and 37,000, respectively). A single mutant, in addition to lacking proteins A, B, and C, was missing a fourth protein of 165,000 molecular weight. The remaining mutants exhibited

Original languageEnglish (US)
Pages (from-to)809-817
Number of pages9
JournalInfection and Immunity
Volume35
Issue number3
StatePublished - Jan 1 1982
Externally publishedYes

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ASJC Scopus subject areas

  • Parasitology
  • Microbiology
  • Immunology
  • Infectious Diseases

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