Identification of magnolol and honokiol as anxiolytic agents in extracts of Saiboku-to, an oriental herbal medicine

Y. Maruyama; H. Kuribara; M. Morita; M. Yuzurihara; S. T. Weintraub

doi:10.1021/np9702446

Identification of magnolol and honokiol as anxiolytic agents in extracts of Saiboku-to, an oriental herbal medicine

Y. Maruyama, H. Kuribara, M. Morita, M. Yuzurihara, S. T. Weintraub

Research output: Contribution to journal › Article › peer-review

147 Scopus citations

Abstract

The principal active anxiolytic components in Saiboku-to, an Oriental herbal medicine, have been isolated and identified as magnolol (5,5'-di-2- propenyl-1,1'-biphenyl-2,2'-diol) and honokiol (3',5-di-2-propenyl-1,1'- biphenyl-2,4'-diol). Evaluation by means of an elevated plus-maze test showed that honokiol was at least 5000 times more potent than Saiboku-to when mice were treated orally for 7 days.

Original language	English (US)
Pages (from-to)	135-138
Number of pages	4
Journal	Journal of Natural Products
Volume	61
Issue number	1
DOIs	https://doi.org/10.1021/np9702446
State	Published - 1998
Externally published	Yes

ASJC Scopus subject areas

Drug Discovery
Analytical Chemistry
Molecular Medicine
Complementary and alternative medicine
Pharmacology
Pharmaceutical Science
Organic Chemistry

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abstract = "The principal active anxiolytic components in Saiboku-to, an Oriental herbal medicine, have been isolated and identified as magnolol (5,5'-di-2- propenyl-1,1'-biphenyl-2,2'-diol) and honokiol (3',5-di-2-propenyl-1,1'- biphenyl-2,4'-diol). Evaluation by means of an elevated plus-maze test showed that honokiol was at least 5000 times more potent than Saiboku-to when mice were treated orally for 7 days.",

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AU - Morita, M.

AU - Yuzurihara, M.

AU - Weintraub, S. T.

PY - 1998

Y1 - 1998

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AB - The principal active anxiolytic components in Saiboku-to, an Oriental herbal medicine, have been isolated and identified as magnolol (5,5'-di-2- propenyl-1,1'-biphenyl-2,2'-diol) and honokiol (3',5-di-2-propenyl-1,1'- biphenyl-2,4'-diol). Evaluation by means of an elevated plus-maze test showed that honokiol was at least 5000 times more potent than Saiboku-to when mice were treated orally for 7 days.

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Identification of magnolol and honokiol as anxiolytic agents in extracts of Saiboku-to, an oriental herbal medicine

Abstract

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