Identification of magnolol and honokiol as anxiolytic agents in extracts of Saiboku-to, an oriental herbal medicine

Y. Maruyama, H. Kuribara, M. Morita, M. Yuzurihara, Susan E Weintraub

Research output: Contribution to journalArticle

129 Citations (Scopus)

Abstract

The principal active anxiolytic components in Saiboku-to, an Oriental herbal medicine, have been isolated and identified as magnolol (5,5'-di-2- propenyl-1,1'-biphenyl-2,2'-diol) and honokiol (3',5-di-2-propenyl-1,1'- biphenyl-2,4'-diol). Evaluation by means of an elevated plus-maze test showed that honokiol was at least 5000 times more potent than Saiboku-to when mice were treated orally for 7 days.

Original languageEnglish (US)
Pages (from-to)135-138
Number of pages4
JournalJournal of Natural Products
Volume61
Issue number1
DOIs
StatePublished - 1998
Externally publishedYes

Fingerprint

East Asian Traditional Medicine
tranquilizers
glycols
Herbal Medicine
herbal medicines
Anti-Anxiety Agents
biphenyl
extracts
mice
testing
honokiol
magnolol
diphenyl
saiboku-to

ASJC Scopus subject areas

  • Plant Science
  • Chemistry (miscellaneous)
  • Drug Discovery
  • Organic Chemistry
  • Pharmacology

Cite this

Identification of magnolol and honokiol as anxiolytic agents in extracts of Saiboku-to, an oriental herbal medicine. / Maruyama, Y.; Kuribara, H.; Morita, M.; Yuzurihara, M.; Weintraub, Susan E.

In: Journal of Natural Products, Vol. 61, No. 1, 1998, p. 135-138.

Research output: Contribution to journalArticle

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