Identification of magnolol and honokiol as anxiolytic agents in extracts of Saiboku-to, an oriental herbal medicine

Y. Maruyama, H. Kuribara, M. Morita, M. Yuzurihara, S. T. Weintraub

Research output: Contribution to journalArticlepeer-review

132 Scopus citations

Abstract

The principal active anxiolytic components in Saiboku-to, an Oriental herbal medicine, have been isolated and identified as magnolol (5,5'-di-2- propenyl-1,1'-biphenyl-2,2'-diol) and honokiol (3',5-di-2-propenyl-1,1'- biphenyl-2,4'-diol). Evaluation by means of an elevated plus-maze test showed that honokiol was at least 5000 times more potent than Saiboku-to when mice were treated orally for 7 days.

Original languageEnglish (US)
Pages (from-to)135-138
Number of pages4
JournalJournal of Natural Products
Volume61
Issue number1
DOIs
StatePublished - Mar 9 1998
Externally publishedYes

ASJC Scopus subject areas

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry

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