Identification of conserved and divergent domains within the envelope gene of the acquired immunodeficiency syndrome retrovirus

R. L. Willey, R. A. Rutledge, S. Dias, T. Folks, T. Theodore, C. E. Buckler, M. A. Martin

    Research output: Contribution to journalArticlepeer-review

    152 Scopus citations

    Abstract

    The nucleotide sequences of the envelope genes of an African and a North American acquired immunodeficiency syndrome (AIDS) viral isolate have been determined. When their deduced amino acid sequences were aligned with the envelopes of the lymphoadenopathy and AIDS-associated retrovirus isolates, conserved and divergent regions were readily identified. Hypervariable stretches of 28-74 amino acids, exhibiting 20-30% amino acid identity at each position and characterized by reciprocal insertions and deletions, were confined to the gp120 external envelope protein. The origin and clinical implications of the AIDS viral env gene diversity are discussed.

    Original languageEnglish (US)
    Pages (from-to)5038-5042
    Number of pages5
    JournalProceedings of the National Academy of Sciences of the United States of America
    Volume83
    Issue number14
    DOIs
    StatePublished - 1986

    ASJC Scopus subject areas

    • General

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