Identification of a second inducible DNA-protein interaction in the kappa immunoglobulin enhancer

Keats Neims, Robert Hromas, Brian van Ness

Research output: Contribution to journalArticle

27 Scopus citations

Abstract

Control of kappa immunoglobulin light-chain gene expression requires the interaction of tissue specific and developmentally regulated DNA-binding proteins with the kappa gene enhancer. Deletion of enhancer sequences upstream from the NF-kB binding site has been shown to impair enhancer function, implying additional proteins may interact with these sequences. in surveying this region for sites of protein binding, a novel DNA-protein interaction, designated kBF-A, was detected. The binding activity of this factor appears to be specific to activated pre-B cells and correlates with high level induction of kappa transcription in these cells.

Original languageEnglish (US)
Pages (from-to)1037-1043
Number of pages7
JournalNucleic acids research
Volume18
Issue number4
DOIs
StatePublished - Feb 25 1990
Externally publishedYes

ASJC Scopus subject areas

  • Genetics

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