Identification of a protective haplogenotype within CAPN10 gene influencing colorectal cancer susceptibility

Carmen P. Frances; Manuel C. Conde; Maria E. Saez; Servando F. Diez; Concha M. Rey; Juan A. Ramírez-Armengol; Manuel H. Pascual; Antonio Gonzalez-Perez; Pablo P. Torres; Luis M. Real; Manuel Serrano-Rios; José L.G. López; Agustin Ruiz; Jose L. Royo

doi:10.1111/j.1440-1746.2007.04843.x

Identification of a protective haplogenotype within CAPN10 gene influencing colorectal cancer susceptibility

Carmen P. Frances, Manuel C. Conde, Maria E. Saez, Servando F. Diez, Concha M. Rey, Juan A. Ramírez-Armengol, Manuel H. Pascual, Antonio Gonzalez-Perez, Pablo P. Torres, Luis M. Real, Manuel Serrano-Rios, José L.G. López, Agustin Ruiz, Jose L. Royo

Research output: Contribution to journal › Article › peer-review

15 Scopus citations

Abstract

Background and Aim: Colorectal cancer (CRC) is one of the most prevalent types of cancer affecting both men and women in developed countries. Clinical and molecular evidence suggests that there are multiple biochemical pathways involved in its susceptibility, pathogenesis and prognosis. Several studies have reported a significant association between the incidence of CRC and type 2 diabetes mellitus (T2DM). However, genes associated with both conditions are rare. Method: We have analyzed the CAPN10 gene, a T2DM locus, using UCSNP-43, -44, -19, and -63 markers, looking for differences between 371 CRC patients and 605 unrelated controls of Spanish origin. Results: We found that UCSNP-44 allele C is swept out from cases (OR = 0.16, P = 0.005). Moreover, the frequency of 2111/2111 haplogenotype is also statistically lower than expected in CRC patients (P = 0.006). Conclusion: Taken together, our results indicate a recessive model for the effect of CAPN10 variant UCSNP-44 influencing the risk of CRC and suggest a novel genetic link between T2DM and colon carcinoma.

Original language	English (US)
Pages (from-to)	2298-2302
Number of pages	5
Journal	Journal of Gastroenterology and Hepatology (Australia)
Volume	22
Issue number	12
DOIs	https://doi.org/10.1111/j.1440-1746.2007.04843.x
State	Published - Dec 2007
Externally published	Yes

Keywords

CAPN10
Colorectal cancer
Diabetes
Pyrosequencing
UCSNP-44

ASJC Scopus subject areas

Hepatology
Gastroenterology

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10.1111/j.1440-1746.2007.04843.x

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Frances, C. P., Conde, M. C., Saez, M. E., Diez, S. F., Rey, C. M., Ramírez-Armengol, J. A., Pascual, M. H., Gonzalez-Perez, A., Torres, P. P., Real, L. M., Serrano-Rios, M., López, J. L. G., Ruiz, A., & Royo, J. L. (2007). Identification of a protective haplogenotype within CAPN10 gene influencing colorectal cancer susceptibility. Journal of Gastroenterology and Hepatology (Australia), 22(12), 2298-2302. https://doi.org/10.1111/j.1440-1746.2007.04843.x

Frances, CP, Conde, MC, Saez, ME, Diez, SF, Rey, CM, Ramírez-Armengol, JA, Pascual, MH, Gonzalez-Perez, A, Torres, PP, Real, LM, Serrano-Rios, M, López, JLG, Ruiz, A & Royo, JL 2007, 'Identification of a protective haplogenotype within CAPN10 gene influencing colorectal cancer susceptibility', Journal of Gastroenterology and Hepatology (Australia), vol. 22, no. 12, pp. 2298-2302. https://doi.org/10.1111/j.1440-1746.2007.04843.x

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title = "Identification of a protective haplogenotype within CAPN10 gene influencing colorectal cancer susceptibility",

abstract = "Background and Aim: Colorectal cancer (CRC) is one of the most prevalent types of cancer affecting both men and women in developed countries. Clinical and molecular evidence suggests that there are multiple biochemical pathways involved in its susceptibility, pathogenesis and prognosis. Several studies have reported a significant association between the incidence of CRC and type 2 diabetes mellitus (T2DM). However, genes associated with both conditions are rare. Method: We have analyzed the CAPN10 gene, a T2DM locus, using UCSNP-43, -44, -19, and -63 markers, looking for differences between 371 CRC patients and 605 unrelated controls of Spanish origin. Results: We found that UCSNP-44 allele C is swept out from cases (OR = 0.16, P = 0.005). Moreover, the frequency of 2111/2111 haplogenotype is also statistically lower than expected in CRC patients (P = 0.006). Conclusion: Taken together, our results indicate a recessive model for the effect of CAPN10 variant UCSNP-44 influencing the risk of CRC and suggest a novel genetic link between T2DM and colon carcinoma.",

keywords = "CAPN10, Colorectal cancer, Diabetes, Pyrosequencing, UCSNP-44",

author = "Frances, \{Carmen P.\} and Conde, \{Manuel C.\} and Saez, \{Maria E.\} and Diez, \{Servando F.\} and Rey, \{Concha M.\} and Ram{\'i}rez-Armengol, \{Juan A.\} and Pascual, \{Manuel H.\} and Antonio Gonzalez-Perez and Torres, \{Pablo P.\} and Real, \{Luis M.\} and Manuel Serrano-Rios and L{\'o}pez, \{Jos{\'e} L.G.\} and Agustin Ruiz and Royo, \{Jose L.\}",

year = "2007",

month = dec,

doi = "10.1111/j.1440-1746.2007.04843.x",

language = "English (US)",

volume = "22",

pages = "2298--2302",

journal = "Journal of Gastroenterology and Hepatology (Australia)",

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T1 - Identification of a protective haplogenotype within CAPN10 gene influencing colorectal cancer susceptibility

AU - Frances, Carmen P.

AU - Conde, Manuel C.

AU - Saez, Maria E.

AU - Diez, Servando F.

AU - Rey, Concha M.

AU - Ramírez-Armengol, Juan A.

AU - Pascual, Manuel H.

AU - Gonzalez-Perez, Antonio

AU - Torres, Pablo P.

AU - Real, Luis M.

AU - Serrano-Rios, Manuel

AU - López, José L.G.

AU - Ruiz, Agustin

AU - Royo, Jose L.

PY - 2007/12

Y1 - 2007/12

N2 - Background and Aim: Colorectal cancer (CRC) is one of the most prevalent types of cancer affecting both men and women in developed countries. Clinical and molecular evidence suggests that there are multiple biochemical pathways involved in its susceptibility, pathogenesis and prognosis. Several studies have reported a significant association between the incidence of CRC and type 2 diabetes mellitus (T2DM). However, genes associated with both conditions are rare. Method: We have analyzed the CAPN10 gene, a T2DM locus, using UCSNP-43, -44, -19, and -63 markers, looking for differences between 371 CRC patients and 605 unrelated controls of Spanish origin. Results: We found that UCSNP-44 allele C is swept out from cases (OR = 0.16, P = 0.005). Moreover, the frequency of 2111/2111 haplogenotype is also statistically lower than expected in CRC patients (P = 0.006). Conclusion: Taken together, our results indicate a recessive model for the effect of CAPN10 variant UCSNP-44 influencing the risk of CRC and suggest a novel genetic link between T2DM and colon carcinoma.

AB - Background and Aim: Colorectal cancer (CRC) is one of the most prevalent types of cancer affecting both men and women in developed countries. Clinical and molecular evidence suggests that there are multiple biochemical pathways involved in its susceptibility, pathogenesis and prognosis. Several studies have reported a significant association between the incidence of CRC and type 2 diabetes mellitus (T2DM). However, genes associated with both conditions are rare. Method: We have analyzed the CAPN10 gene, a T2DM locus, using UCSNP-43, -44, -19, and -63 markers, looking for differences between 371 CRC patients and 605 unrelated controls of Spanish origin. Results: We found that UCSNP-44 allele C is swept out from cases (OR = 0.16, P = 0.005). Moreover, the frequency of 2111/2111 haplogenotype is also statistically lower than expected in CRC patients (P = 0.006). Conclusion: Taken together, our results indicate a recessive model for the effect of CAPN10 variant UCSNP-44 influencing the risk of CRC and suggest a novel genetic link between T2DM and colon carcinoma.

KW - CAPN10

KW - Colorectal cancer

KW - Diabetes

KW - Pyrosequencing

KW - UCSNP-44

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Identification of a protective haplogenotype within CAPN10 gene influencing colorectal cancer susceptibility

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Keywords

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