Identification of a potent kinase inhibitor targeting EML4-ALK fusion protein in non-small cell lung cancer

Lian Xiang Luo; Ying Li; Yu Zhen Niu; Yu Wei Wang; Qian Qian Wang; Xing Xing Fan; Jia Hui Xu; Liang Liu; Elaine Lai Han Leung; Xiao Jun Yao

doi:10.1039/c7md00305f

Identification of a potent kinase inhibitor targeting EML4-ALK fusion protein in non-small cell lung cancer

Lian Xiang Luo, Ying Li, Yu Zhen Niu, Yu Wei Wang, Qian Qian Wang, Xing Xing Fan, Jia Hui Xu, Liang Liu, Elaine Lai Han Leung, Xiao Jun Yao

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

ALK-fusion proteins play a fundamental role in the development of about 5% of non-small cell lung cancers. Herein, we identified the compound 5067-0952 as a potent ALK inhibitor, which inhibited cell growth, induced apoptosis, and suppressed the phosphorylation of ALK, subsequently blocking its downstream signaling pathway.

Original language	English (US)
Pages (from-to)	1914-1918
Number of pages	5
Journal	MedChemComm
Volume	8
Issue number	10
DOIs	https://doi.org/10.1039/c7md00305f
State	Published - 2017
Externally published	Yes

ASJC Scopus subject areas

Biochemistry
Molecular Medicine
Pharmacology
Pharmaceutical Science
Drug Discovery
Organic Chemistry

Access to Document

10.1039/c7md00305f

Cite this

@article{f2bf8af553824b7eb5b15a6993be8d70,

title = "Identification of a potent kinase inhibitor targeting EML4-ALK fusion protein in non-small cell lung cancer",

abstract = "ALK-fusion proteins play a fundamental role in the development of about 5% of non-small cell lung cancers. Herein, we identified the compound 5067-0952 as a potent ALK inhibitor, which inhibited cell growth, induced apoptosis, and suppressed the phosphorylation of ALK, subsequently blocking its downstream signaling pathway.",

author = "Luo, {Lian Xiang} and Ying Li and Niu, {Yu Zhen} and Wang, {Yu Wei} and Wang, {Qian Qian} and Fan, {Xing Xing} and Xu, {Jia Hui} and Liang Liu and Leung, {Elaine Lai Han} and Yao, {Xiao Jun}",

note = "Publisher Copyright: {\textcopyright} 2017 The Royal Society of Chemistry.",

year = "2017",

doi = "10.1039/c7md00305f",

language = "English (US)",

volume = "8",

pages = "1914--1918",

journal = "MedChemComm",

issn = "2040-2503",

publisher = "Royal Society of Chemistry",

number = "10",

}

TY - JOUR

T1 - Identification of a potent kinase inhibitor targeting EML4-ALK fusion protein in non-small cell lung cancer

AU - Luo, Lian Xiang

AU - Li, Ying

AU - Niu, Yu Zhen

AU - Wang, Yu Wei

AU - Wang, Qian Qian

AU - Fan, Xing Xing

AU - Xu, Jia Hui

AU - Liu, Liang

AU - Leung, Elaine Lai Han

AU - Yao, Xiao Jun

PY - 2017

Y1 - 2017

N2 - ALK-fusion proteins play a fundamental role in the development of about 5% of non-small cell lung cancers. Herein, we identified the compound 5067-0952 as a potent ALK inhibitor, which inhibited cell growth, induced apoptosis, and suppressed the phosphorylation of ALK, subsequently blocking its downstream signaling pathway.

AB - ALK-fusion proteins play a fundamental role in the development of about 5% of non-small cell lung cancers. Herein, we identified the compound 5067-0952 as a potent ALK inhibitor, which inhibited cell growth, induced apoptosis, and suppressed the phosphorylation of ALK, subsequently blocking its downstream signaling pathway.

UR - http://www.scopus.com/inward/record.url?scp=85031941300&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85031941300&partnerID=8YFLogxK

U2 - 10.1039/c7md00305f

DO - 10.1039/c7md00305f

M3 - Article

AN - SCOPUS:85031941300

SN - 2040-2503

VL - 8

SP - 1914

EP - 1918

JO - MedChemComm

JF - MedChemComm

IS - 10

ER -

Identification of a potent kinase inhibitor targeting EML4-ALK fusion protein in non-small cell lung cancer

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this