Identification of a chlamydial protease-like activity factor responsible for the degradation of host transcription factors

Guangming Zhong, Peiyi Fan, Hezhao Ji, Feng Dong, Yanqing Huang

Research output: Contribution to journalArticle

308 Scopus citations

Abstract

Microbial pathogens have been selected for the capacity to evade or manipulate host responses in order to survive after infection. Chlamydia, an obligate intracellular pathogen and the causative agent for many human diseases, can escape T lymphocyte immune recognition by degrading host transcription factors required for major histocompatibility complex (MHC) antigen expression. We have now identified a chlamydial protease- or proteasome-like activity factor (CPAF) that is secreted into the host cell cytosol and that is both necessary and sufficient for the degradation of host transcription factors RFX5 and upstream stimulation factor 1 (USF-1). The CPAF gene is highly conserved among chlamydial strains, but has no significant overall homology with other known genes. Thus, CPAF represents a unique secreted protein produced by an obligate intracellular bacterial pathogen to interfere with effective host adaptive immunity.

Original languageEnglish (US)
Pages (from-to)935-942
Number of pages8
JournalJournal of Experimental Medicine
Volume193
Issue number8
DOIs
StatePublished - Apr 16 2001

Keywords

  • Antigen presentation
  • Chlamydial enzyme
  • Degradation
  • Immune evasion
  • Transcription factors

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Fingerprint Dive into the research topics of 'Identification of a chlamydial protease-like activity factor responsible for the degradation of host transcription factors'. Together they form a unique fingerprint.

Cite this