Identification and characterization of an extended tax protein in human T- cell lymphotropic virus type II subtype b isolates

D. Pardi, J. E. Kaplan, J. E. Coligan, T. M. Folks, R. B. Lal

    Research output: Contribution to journalComment/debatepeer-review

    22 Scopus citations

    Abstract

    The tax gene sequence of human T-cell lymphotropic virus type II isolate G12 (HTLV-II(G12)) was found to encode an extended Tax protein when compared with that of HTLV-II(MoT). In vitro transcription-translation of the HTLV- II(G12) tax gene produced a 40-kDa Tax protein that specifically reacted with serum specimens from HTLV-II-infected individuals. Limited sequence analysis demonstrated that isolates with an extended Tax protein were all HTLV-II subtype b (HTLV-IIb). Therefore, the extended Tax protein appears to be a unique characteristic of most HTLV-IIb isolates and may be useful in designing immunoassays to distinguish between HTLV-IIa and HTLV-IIb.

    Original languageEnglish (US)
    Pages (from-to)7663-7667
    Number of pages5
    JournalJournal of virology
    Volume67
    Issue number12
    DOIs
    StatePublished - 1993

    ASJC Scopus subject areas

    • Microbiology
    • Immunology
    • Insect Science
    • Virology

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