Abstract
The tax gene sequence of human T-cell lymphotropic virus type II isolate G12 (HTLV-II(G12)) was found to encode an extended Tax protein when compared with that of HTLV-II(MoT). In vitro transcription-translation of the HTLV- II(G12) tax gene produced a 40-kDa Tax protein that specifically reacted with serum specimens from HTLV-II-infected individuals. Limited sequence analysis demonstrated that isolates with an extended Tax protein were all HTLV-II subtype b (HTLV-IIb). Therefore, the extended Tax protein appears to be a unique characteristic of most HTLV-IIb isolates and may be useful in designing immunoassays to distinguish between HTLV-IIa and HTLV-IIb.
Original language | English (US) |
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Pages (from-to) | 7663-7667 |
Number of pages | 5 |
Journal | Journal of virology |
Volume | 67 |
Issue number | 12 |
DOIs |
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State | Published - 1993 |
ASJC Scopus subject areas
- Microbiology
- Immunology
- Insect Science
- Virology