The tax gene sequence of human T-cell lymphotropic virus type II isolate G12 (HTLV-II(G12)) was found to encode an extended Tax protein when compared with that of HTLV-II(MoT). In vitro transcription-translation of the HTLV- II(G12) tax gene produced a 40-kDa Tax protein that specifically reacted with serum specimens from HTLV-II-infected individuals. Limited sequence analysis demonstrated that isolates with an extended Tax protein were all HTLV-II subtype b (HTLV-IIb). Therefore, the extended Tax protein appears to be a unique characteristic of most HTLV-IIb isolates and may be useful in designing immunoassays to distinguish between HTLV-IIa and HTLV-IIb.
ASJC Scopus subject areas
- Insect Science