Abstract
The tax gene sequence of human T-cell lymphotropic virus type II isolate G12 (HTLV-IIG12) was found to encode an extended Tax protein when compared with that of HTLV-IIMoT. In vitro transcription-translation of the HTLV-IIG12 tax gene produced a 40-kDa Tax protein that specifically reacted with serum specimens from HTLV-II-infected individuals. Limited sequence analysis demonstrated that isolates with an extended Tax protein were all HTLV-II subtype b (HTLV-IIb). Therefore, the extended Tax protein appears to be a unique characteristic of most HTLV-IIb isolates and may be useful in designing immunoassays to distinguish between HTLV-IIa and HTLV-IIb.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 7663-7667 |
| Number of pages | 5 |
| Journal | Journal of Virology |
| Volume | 67 |
| Issue number | 12 |
| State | Published - Dec 1993 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Immunology
Cite this
Identification and characterization of an extended tax protein in human T-cell lymphotropic virus type II subtype b isolates. / Pardi, Diane; Kaplan, Jonathan E.; Coligan, John E.; Folks, Thomas M.; Lal, Renu B.
In: Journal of Virology, Vol. 67, No. 12, 12.1993, p. 7663-7667.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Identification and characterization of an extended tax protein in human T-cell lymphotropic virus type II subtype b isolates
AU - Pardi, Diane
AU - Kaplan, Jonathan E.
AU - Coligan, John E.
AU - Folks, Thomas M.
AU - Lal, Renu B.
PY - 1993/12
Y1 - 1993/12
N2 - The tax gene sequence of human T-cell lymphotropic virus type II isolate G12 (HTLV-IIG12) was found to encode an extended Tax protein when compared with that of HTLV-IIMoT. In vitro transcription-translation of the HTLV-IIG12 tax gene produced a 40-kDa Tax protein that specifically reacted with serum specimens from HTLV-II-infected individuals. Limited sequence analysis demonstrated that isolates with an extended Tax protein were all HTLV-II subtype b (HTLV-IIb). Therefore, the extended Tax protein appears to be a unique characteristic of most HTLV-IIb isolates and may be useful in designing immunoassays to distinguish between HTLV-IIa and HTLV-IIb.
AB - The tax gene sequence of human T-cell lymphotropic virus type II isolate G12 (HTLV-IIG12) was found to encode an extended Tax protein when compared with that of HTLV-IIMoT. In vitro transcription-translation of the HTLV-IIG12 tax gene produced a 40-kDa Tax protein that specifically reacted with serum specimens from HTLV-II-infected individuals. Limited sequence analysis demonstrated that isolates with an extended Tax protein were all HTLV-II subtype b (HTLV-IIb). Therefore, the extended Tax protein appears to be a unique characteristic of most HTLV-IIb isolates and may be useful in designing immunoassays to distinguish between HTLV-IIa and HTLV-IIb.
UR - http://www.scopus.com/inward/record.url?scp=0027448645&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0027448645&partnerID=8YFLogxK
M3 - Article
C2 - 8230487
AN - SCOPUS:0027448645
VL - 67
SP - 7663
EP - 7667
JO - Journal of Virology
JF - Journal of Virology
SN - 0022-538X
IS - 12
ER -