Identification and characterization of an extended tax protein in human T-cell lymphotropic virus type II subtype b isolates

Diane Pardi, Jonathan E. Kaplan, John E. Coligan, Thomas M. Folks, Renu B. Lal

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

The tax gene sequence of human T-cell lymphotropic virus type II isolate G12 (HTLV-IIG12) was found to encode an extended Tax protein when compared with that of HTLV-IIMoT. In vitro transcription-translation of the HTLV-IIG12 tax gene produced a 40-kDa Tax protein that specifically reacted with serum specimens from HTLV-II-infected individuals. Limited sequence analysis demonstrated that isolates with an extended Tax protein were all HTLV-II subtype b (HTLV-IIb). Therefore, the extended Tax protein appears to be a unique characteristic of most HTLV-IIb isolates and may be useful in designing immunoassays to distinguish between HTLV-IIa and HTLV-IIb.

Original languageEnglish (US)
Pages (from-to)7663-7667
Number of pages5
JournalJournal of Virology
Volume67
Issue number12
StatePublished - Dec 1993
Externally publishedYes

Fingerprint

tax Gene Products
Human T-lymphotropic virus 2
taxes
T-lymphocytes
T-Lymphocytes
pX Genes
viruses
proteins
Immunoassay
Sequence Analysis
immunoassays
translation (genetics)
sequence analysis
transcription (genetics)
nucleotide sequences
Serum

ASJC Scopus subject areas

  • Immunology

Cite this

Pardi, D., Kaplan, J. E., Coligan, J. E., Folks, T. M., & Lal, R. B. (1993). Identification and characterization of an extended tax protein in human T-cell lymphotropic virus type II subtype b isolates. Journal of Virology, 67(12), 7663-7667.

Identification and characterization of an extended tax protein in human T-cell lymphotropic virus type II subtype b isolates. / Pardi, Diane; Kaplan, Jonathan E.; Coligan, John E.; Folks, Thomas M.; Lal, Renu B.

In: Journal of Virology, Vol. 67, No. 12, 12.1993, p. 7663-7667.

Research output: Contribution to journalArticle

Pardi, D, Kaplan, JE, Coligan, JE, Folks, TM & Lal, RB 1993, 'Identification and characterization of an extended tax protein in human T-cell lymphotropic virus type II subtype b isolates', Journal of Virology, vol. 67, no. 12, pp. 7663-7667.
Pardi, Diane ; Kaplan, Jonathan E. ; Coligan, John E. ; Folks, Thomas M. ; Lal, Renu B. / Identification and characterization of an extended tax protein in human T-cell lymphotropic virus type II subtype b isolates. In: Journal of Virology. 1993 ; Vol. 67, No. 12. pp. 7663-7667.
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