Identification and characterization of an extended tax protein in human T- cell lymphotropic virus type II subtype b isolates

D. Pardi; J. E. Kaplan; J. E. Coligan; T. M. Folks; R. B. Lal

doi:10.1128/jvi.67.12.7663-7667.1993

Identification and characterization of an extended tax protein in human T- cell lymphotropic virus type II subtype b isolates

D. Pardi, J. E. Kaplan, J. E. Coligan, T. M. Folks, R. B. Lal

Research output: Contribution to journal › Comment/debate › peer-review

22 Scopus citations

Abstract

The tax gene sequence of human T-cell lymphotropic virus type II isolate G12 (HTLV-II(G12)) was found to encode an extended Tax protein when compared with that of HTLV-II(MoT). In vitro transcription-translation of the HTLV- II(G12) tax gene produced a 40-kDa Tax protein that specifically reacted with serum specimens from HTLV-II-infected individuals. Limited sequence analysis demonstrated that isolates with an extended Tax protein were all HTLV-II subtype b (HTLV-IIb). Therefore, the extended Tax protein appears to be a unique characteristic of most HTLV-IIb isolates and may be useful in designing immunoassays to distinguish between HTLV-IIa and HTLV-IIb.

Original language	English (US)
Pages (from-to)	7663-7667
Number of pages	5
Journal	Journal of virology
Volume	67
Issue number	12
DOIs	https://doi.org/10.1128/jvi.67.12.7663-7667.1993
State	Published - 1993

ASJC Scopus subject areas

Microbiology
Immunology
Insect Science
Virology

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title = "Identification and characterization of an extended tax protein in human T- cell lymphotropic virus type II subtype b isolates",

abstract = "The tax gene sequence of human T-cell lymphotropic virus type II isolate G12 (HTLV-II(G12)) was found to encode an extended Tax protein when compared with that of HTLV-II(MoT). In vitro transcription-translation of the HTLV- II(G12) tax gene produced a 40-kDa Tax protein that specifically reacted with serum specimens from HTLV-II-infected individuals. Limited sequence analysis demonstrated that isolates with an extended Tax protein were all HTLV-II subtype b (HTLV-IIb). Therefore, the extended Tax protein appears to be a unique characteristic of most HTLV-IIb isolates and may be useful in designing immunoassays to distinguish between HTLV-IIa and HTLV-IIb.",

author = "D. Pardi and Kaplan, {J. E.} and Coligan, {J. E.} and Folks, {T. M.} and Lal, {R. B.}",

year = "1993",

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T1 - Identification and characterization of an extended tax protein in human T- cell lymphotropic virus type II subtype b isolates

AU - Pardi, D.

AU - Kaplan, J. E.

AU - Coligan, J. E.

AU - Folks, T. M.

AU - Lal, R. B.

PY - 1993

Y1 - 1993

N2 - The tax gene sequence of human T-cell lymphotropic virus type II isolate G12 (HTLV-II(G12)) was found to encode an extended Tax protein when compared with that of HTLV-II(MoT). In vitro transcription-translation of the HTLV- II(G12) tax gene produced a 40-kDa Tax protein that specifically reacted with serum specimens from HTLV-II-infected individuals. Limited sequence analysis demonstrated that isolates with an extended Tax protein were all HTLV-II subtype b (HTLV-IIb). Therefore, the extended Tax protein appears to be a unique characteristic of most HTLV-IIb isolates and may be useful in designing immunoassays to distinguish between HTLV-IIa and HTLV-IIb.

AB - The tax gene sequence of human T-cell lymphotropic virus type II isolate G12 (HTLV-II(G12)) was found to encode an extended Tax protein when compared with that of HTLV-II(MoT). In vitro transcription-translation of the HTLV- II(G12) tax gene produced a 40-kDa Tax protein that specifically reacted with serum specimens from HTLV-II-infected individuals. Limited sequence analysis demonstrated that isolates with an extended Tax protein were all HTLV-II subtype b (HTLV-IIb). Therefore, the extended Tax protein appears to be a unique characteristic of most HTLV-IIb isolates and may be useful in designing immunoassays to distinguish between HTLV-IIa and HTLV-IIb.

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