Ibrexafungerp: A novel oral glucan synthase inhibitor

M. R. Davis, M. A. Donnelley, G. R. Thompson

Research output: Contribution to journalArticle

7 Scopus citations

Abstract

Ibrexafungerp is a novel glucan synthase inhibitor currently undergoing phase II and phase III clinical trials. This compound has demonstrated in vitro activity against clinically important fungal pathogens including Candida spp. and Aspergillus spp. It is able to retain activity against many echinocandin-resistant strains of Candida due to differential avidity for the target site compared to echinocandins. In vivo animal models have demonstrated efficacy in murine models of invasive candidiasis, aspergillosis, and pneumocystis. Due to high bioavailability, it can be administered both orally and intravenously. A favorable drug interaction and tolerability profile is observed with this compound. This review summarizes existing data that have either been published or presented at international symposia.

Original languageEnglish (US)
Pages (from-to)579-592
Number of pages14
JournalMedical mycology
Volume58
Issue number5
DOIs
StatePublished - Jul 1 2020
Externally publishedYes

Keywords

  • antifungal
  • aspergillosis
  • candidiasis
  • in vitro activity
  • in vivo studies

ASJC Scopus subject areas

  • Infectious Diseases

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