Hypoxia in astrocytic tumors and implications for therapy

David A. Cavazos, Andrew Brenner

Research output: Contribution to journalArticle

13 Scopus citations

Abstract

Glioblastoma (GBM, Grade IV astrocytoma) is the most common and most aggressive of the primary malignant brain tumors in adults. Hypoxia is a distinct feature in GBM and plays a significant role in tumor progression, resistance to treatment and poor outcomes. This review considers the effects of hypoxia on astrocytic tumors and the mechanisms that contribute to tumor progression and therapeutic resistance, with a focus on the vascular changes, chemotaxic signaling pathways and metabolic alterations involved.

Original languageEnglish (US)
Pages (from-to)227-233
Number of pages7
JournalNeurobiology of Disease
Volume85
DOIs
StatePublished - Jan 1 2016

Keywords

  • Acetate
  • Aerobic glycolysis
  • Astrocytic tumors
  • CXCL12
  • CXCR7
  • Glioblastoma multiforme
  • Hypoxia
  • Metabolic derangement
  • Pseudopalisading necrosis
  • TH-302

ASJC Scopus subject areas

  • Neurology

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