Hypoxia in astrocytic tumors and implications for therapy

David A. Cavazos; Andrew J. Brenner

doi:10.1016/j.nbd.2015.06.007

Hypoxia in astrocytic tumors and implications for therapy

David A. Cavazos, Andrew J. Brenner

Department of Medicine

Research output: Contribution to journal › Review article › peer-review

28 Scopus citations

Abstract

Glioblastoma (GBM, Grade IV astrocytoma) is the most common and most aggressive of the primary malignant brain tumors in adults. Hypoxia is a distinct feature in GBM and plays a significant role in tumor progression, resistance to treatment and poor outcomes. This review considers the effects of hypoxia on astrocytic tumors and the mechanisms that contribute to tumor progression and therapeutic resistance, with a focus on the vascular changes, chemotaxic signaling pathways and metabolic alterations involved.

Original language	English (US)
Pages (from-to)	227-233
Number of pages	7
Journal	Neurobiology of Disease
Volume	85
DOIs	https://doi.org/10.1016/j.nbd.2015.06.007
State	Published - Jan 1 2016

Keywords

Acetate
Aerobic glycolysis
Astrocytic tumors
CXCL12
CXCR7
Glioblastoma multiforme
Hypoxia
Metabolic derangement
Pseudopalisading necrosis
TH-302

ASJC Scopus subject areas

Neurology

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10.1016/j.nbd.2015.06.007

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title = "Hypoxia in astrocytic tumors and implications for therapy",

abstract = "Glioblastoma (GBM, Grade IV astrocytoma) is the most common and most aggressive of the primary malignant brain tumors in adults. Hypoxia is a distinct feature in GBM and plays a significant role in tumor progression, resistance to treatment and poor outcomes. This review considers the effects of hypoxia on astrocytic tumors and the mechanisms that contribute to tumor progression and therapeutic resistance, with a focus on the vascular changes, chemotaxic signaling pathways and metabolic alterations involved.",

keywords = "Acetate, Aerobic glycolysis, Astrocytic tumors, CXCL12, CXCR7, Glioblastoma multiforme, Hypoxia, Metabolic derangement, Pseudopalisading necrosis, TH-302",

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AU - Brenner, Andrew J.

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AB - Glioblastoma (GBM, Grade IV astrocytoma) is the most common and most aggressive of the primary malignant brain tumors in adults. Hypoxia is a distinct feature in GBM and plays a significant role in tumor progression, resistance to treatment and poor outcomes. This review considers the effects of hypoxia on astrocytic tumors and the mechanisms that contribute to tumor progression and therapeutic resistance, with a focus on the vascular changes, chemotaxic signaling pathways and metabolic alterations involved.

KW - Acetate

KW - Aerobic glycolysis

KW - Astrocytic tumors

KW - CXCL12

KW - CXCR7

KW - Glioblastoma multiforme

KW - Hypoxia

KW - Metabolic derangement

KW - Pseudopalisading necrosis

KW - TH-302

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DO - 10.1016/j.nbd.2015.06.007

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AN - SCOPUS:84949727975

SN - 0969-9961

VL - 85

SP - 227

EP - 233

JO - Neurobiology of Disease

JF - Neurobiology of Disease

ER -

Hypoxia in astrocytic tumors and implications for therapy

Abstract

Keywords

ASJC Scopus subject areas

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