Hypoxia in astrocytic tumors and implications for therapy

David A. Cavazos, Andrew J. Brenner

Research output: Contribution to journalReview articlepeer-review

27 Scopus citations


Glioblastoma (GBM, Grade IV astrocytoma) is the most common and most aggressive of the primary malignant brain tumors in adults. Hypoxia is a distinct feature in GBM and plays a significant role in tumor progression, resistance to treatment and poor outcomes. This review considers the effects of hypoxia on astrocytic tumors and the mechanisms that contribute to tumor progression and therapeutic resistance, with a focus on the vascular changes, chemotaxic signaling pathways and metabolic alterations involved.

Original languageEnglish (US)
Pages (from-to)227-233
Number of pages7
JournalNeurobiology of Disease
StatePublished - Jan 1 2016


  • Acetate
  • Aerobic glycolysis
  • Astrocytic tumors
  • CXCL12
  • CXCR7
  • Glioblastoma multiforme
  • Hypoxia
  • Metabolic derangement
  • Pseudopalisading necrosis
  • TH-302

ASJC Scopus subject areas

  • Neurology


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