Hypothesizing in the Face of the Opioid Crisis Coupling Genetic Addiction Risk Severity (GARS) Testing with Electrotherapeutic Nonopioid Modalities Such As H-Wave Could Attenuate Both Pain and Hedonic Addictive Behaviors

Ashim Gupta, Abdalla Bowirrat, Luis Llanos Gomez, David Baron, Igor Elman, John Giordano, Rehan Jalali, Rajendra D. Badgaiyan, Edward J. Modestino, Mark S. Gold, Eric R. Braverman, Anish Bajaj, Kenneth Blum

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

In the United States, amid the opioid overdose epidemic, nonaddicting/nonpharmacological proven strategies are available to treat pain and manage chronic pain effectively without opioids. Evidence supporting the long-term use of opioids for pain is lacking, as is the will to alter the drug-embracing culture in American chronic pain management. Some pain clinicians seem to prefer classical analgesic agents that promote unwanted tolerance to analgesics and subsequent biological induction of the “addictive brain”. Reward genes play a vital part in modulation of nociception and adaptations in the dopaminergic circuitry. They may affect various sensory and affective components of the chronic pain syndromes. The Genetic Addiction Risk Severity (GARS) test coupled with the H-Wave at entry in pain clinics could attenuate pain and help prevent addiction. The GARS test results identify high-risk for both drug and alcohol, and H-Wave can be initiated to treat pain instead of opioids. The utilization of H-Wave to aid in pain reduction and mitigation of hedonic addictive behaviors is recommended, notwithstanding required randomized control studies. This frontline approach would reduce the possibility of long-term neurobiological deficits and fatalities associated with potent opioid analgesics.

Original languageEnglish (US)
Article number552
JournalInternational Journal of Environmental Research and Public Health
Volume19
Issue number1
DOIs
StatePublished - Jan 1 2022

Keywords

  • Genetic Addiction Risk Severity (GARS)
  • H-Wave
  • Hypodopaminism
  • RDS
  • Reward Deficiency Syndrome
  • Substance use disorder

ASJC Scopus subject areas

  • Pollution
  • Public Health, Environmental and Occupational Health
  • Health, Toxicology and Mutagenesis

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