Hypothalamic responsiveness to oestrogen in hypothyroid rats

N. Hagino

Research output: Contribution to journalArticlepeer-review

1 Scopus citations


When 50 iu of PMS is given at 28 days of age, ovulation occurs on day 31, in thyroidectomized rats receiving PMS at 28 days of age, ovulation on days 30 and 31. PMS treated thyroidectomized rats were given 0.5 μg oestrogen at 9 a.m. on day 29 or 30. Injection on day 29 increases ovulation, but the injection on day 30 has no effect. Injection of 1.0 μg oestrogen on day 29 reduces activity, however, 1.0 μg on day 30 increases ovulation. These results infer that the hypothyroid state in PMS treated rats significantly alters hypothalamic responsiveness to oestrogen.

Original languageEnglish (US)
Pages (from-to)85-88
Number of pages4
JournalActa Biologica Academiae Scientiarum Hungaricae
Issue number1-2
StatePublished - 1975
Externally publishedYes

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)


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