Hypothalamic dopamine may play a role in inducing prolactin in pituitary cells

N. Hagino; Kinji Inoue

doi:10.1016/0736-5748(86)90036-5

Hypothalamic dopamine may play a role in inducing prolactin in pituitary cells

N. Hagino, Kinji Inoue

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

The effects of hypothalamic dopamine on the functional differentiation of prolactin cells was investigated in the developing rat brain. The treatment of pregnant rats with α-methyl-p-tyrosine (tyrosine hydroxylase inhibitor) resulted in a noticeable decrease of dopamine concentration in the hypothalamus at birth and at 5 days of age of offspring. Moreover, treatment with this regimen caused a marked decrease in the population of prolactin cells and in the production of prolactin at birth and at 5 days of age of offspring. It seems, then, that hypothalamic dopaminergic neurons precede the functional differentiation of prolactin cells in the developing brains and that hypothalamic dopamine may play an important role in producing prolactin in the anterior pituitary during development.

Original language	English (US)
Pages (from-to)	119-128
Number of pages	10
Journal	International Journal of Developmental Neuroscience
Volume	4
Issue number	2
DOIs	https://doi.org/10.1016/0736-5748(86)90036-5
State	Published - 1986
Externally published	Yes

Keywords

Dopamine
Fetuses
Neonates
Prolactin
Rat

ASJC Scopus subject areas

Developmental Neuroscience
Developmental Biology

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10.1016/0736-5748(86)90036-5

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title = "Hypothalamic dopamine may play a role in inducing prolactin in pituitary cells",

abstract = "The effects of hypothalamic dopamine on the functional differentiation of prolactin cells was investigated in the developing rat brain. The treatment of pregnant rats with α-methyl-p-tyrosine (tyrosine hydroxylase inhibitor) resulted in a noticeable decrease of dopamine concentration in the hypothalamus at birth and at 5 days of age of offspring. Moreover, treatment with this regimen caused a marked decrease in the population of prolactin cells and in the production of prolactin at birth and at 5 days of age of offspring. It seems, then, that hypothalamic dopaminergic neurons precede the functional differentiation of prolactin cells in the developing brains and that hypothalamic dopamine may play an important role in producing prolactin in the anterior pituitary during development.",

keywords = "Dopamine, Fetuses, Neonates, Prolactin, Rat",

author = "N. Hagino and Kinji Inoue",

note = "Funding Information: Acknowl~dgemPnrs-The authors express their graditude to Mr John W. Lee and M. K. Liu for their assistance in the laboratory and L. Cifone. D. Miller and V. Bell for the preparation of this manuscript. The study was supported hy USPHS grant NICHD HD-10071 and Ministry of Education, Government of Japan.",

year = "1986",

doi = "10.1016/0736-5748(86)90036-5",

language = "English (US)",

volume = "4",

pages = "119--128",

journal = "International Journal of Developmental Neuroscience",

issn = "0736-5748",

publisher = "Elsevier Limited",

number = "2",

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TY - JOUR

T1 - Hypothalamic dopamine may play a role in inducing prolactin in pituitary cells

AU - Hagino, N.

AU - Inoue, Kinji

N1 - Funding Information: Acknowl~dgemPnrs-The authors express their graditude to Mr John W. Lee and M. K. Liu for their assistance in the laboratory and L. Cifone. D. Miller and V. Bell for the preparation of this manuscript. The study was supported hy USPHS grant NICHD HD-10071 and Ministry of Education, Government of Japan.

PY - 1986

Y1 - 1986

N2 - The effects of hypothalamic dopamine on the functional differentiation of prolactin cells was investigated in the developing rat brain. The treatment of pregnant rats with α-methyl-p-tyrosine (tyrosine hydroxylase inhibitor) resulted in a noticeable decrease of dopamine concentration in the hypothalamus at birth and at 5 days of age of offspring. Moreover, treatment with this regimen caused a marked decrease in the population of prolactin cells and in the production of prolactin at birth and at 5 days of age of offspring. It seems, then, that hypothalamic dopaminergic neurons precede the functional differentiation of prolactin cells in the developing brains and that hypothalamic dopamine may play an important role in producing prolactin in the anterior pituitary during development.

AB - The effects of hypothalamic dopamine on the functional differentiation of prolactin cells was investigated in the developing rat brain. The treatment of pregnant rats with α-methyl-p-tyrosine (tyrosine hydroxylase inhibitor) resulted in a noticeable decrease of dopamine concentration in the hypothalamus at birth and at 5 days of age of offspring. Moreover, treatment with this regimen caused a marked decrease in the population of prolactin cells and in the production of prolactin at birth and at 5 days of age of offspring. It seems, then, that hypothalamic dopaminergic neurons precede the functional differentiation of prolactin cells in the developing brains and that hypothalamic dopamine may play an important role in producing prolactin in the anterior pituitary during development.

KW - Dopamine

KW - Fetuses

KW - Neonates

KW - Prolactin

KW - Rat

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ER -

Hypothalamic dopamine may play a role in inducing prolactin in pituitary cells

Abstract

Keywords

ASJC Scopus subject areas

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