Hypothalamic dopamine may play a role in inducing prolactin in pituitary cells

N. Hagino, Kinji Inoue

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

The effects of hypothalamic dopamine on the functional differentiation of prolactin cells was investigated in the developing rat brain. The treatment of pregnant rats with α-methyl-p-tyrosine (tyrosine hydroxylase inhibitor) resulted in a noticeable decrease of dopamine concentration in the hypothalamus at birth and at 5 days of age of offspring. Moreover, treatment with this regimen caused a marked decrease in the population of prolactin cells and in the production of prolactin at birth and at 5 days of age of offspring. It seems, then, that hypothalamic dopaminergic neurons precede the functional differentiation of prolactin cells in the developing brains and that hypothalamic dopamine may play an important role in producing prolactin in the anterior pituitary during development.

Original languageEnglish (US)
Pages (from-to)119-128
Number of pages10
JournalInternational Journal of Developmental Neuroscience
Volume4
Issue number2
DOIs
StatePublished - 1986
Externally publishedYes

Keywords

  • Dopamine
  • Fetuses
  • Neonates
  • Prolactin
  • Rat

ASJC Scopus subject areas

  • Developmental Neuroscience
  • Developmental Biology

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