Hypotensive effects of lesions of the rostral ventrolateral medulla in rats are anesthetic-dependent

Karen L. Cochrane, R. Allan Buchholz, John W. Hubbard, T. Kent Keeton, Marc A. Nathan

Research output: Contribution to journalArticlepeer-review

26 Scopus citations

Abstract

These studies were designed to determine if the hypotensive effects of bilateral electrolytic lesions of the rostral ventrolateral medulla are dependent on the type of anesthetic agent used. The lesions caused an immediate fall in mean arterial pressure (MAP) in rats anesthetized with urethane, α-chloralose or sodium pentobarbital. At 30 min after placement of the lesions, severe hypotension (MAP = 54 ± 5 mm Hg) persisted in the rats anesthetized with urethane. However, 30 min after placement of the lesions, the MAP of rats anesthetized with α-chloralose or sodium pentobarbital was 87 ± 9 mm Hg and 99 ± 10 mm Hg, respectively. Subsequent transection of the cervical spinal cord produced a much greater decrease in MAP in rats anesthetized with α-chloralose and sodium pentobarbital as compared to rats anesthetized with urethane. Heart rate was significantly lower after placement of the lesions in all 3 groups. We conclude that the magnitude of the hypotensive effect caused by placement of lesions in the rostral ventrolateral medulla is anesthetic-dependent and that the rostral ventrolateral medulla is not the only area of the central nervous system capable of maintaining vasomotor tone.

Original languageEnglish (US)
Pages (from-to)181-187
Number of pages7
JournalJournal of the Autonomic Nervous System
Volume22
Issue number3
DOIs
StatePublished - Apr 1988

Keywords

  • Arterial pressure
  • Rostral ventrolateral medulla
  • Sodium pentobarbital
  • Urethane
  • Vasomotor center
  • α-Chloralose

ASJC Scopus subject areas

  • Neuroscience(all)
  • Physiology
  • Clinical Neurology

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