Hypophonia in Parkinson disease: Neural correlates of voice treatment with LSVT revealed by PET

Mario Liotti, Lorraine Ramig, Deanie Vogel, Pamela New, Chris Cook, Peter T Fox

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

This study investigated the neural correlates of hypophonia in individuals with Idiopathic Parkinson's disease (IPD) before and after the Lee Silverman Voice Treatment (LSVT), using 15O-H2O Positron Emission Tomography (PET). Regional cerebral blood flow (rCBF) changes associated with overt speech-motor tasks relative to the resting state were measured in the IPD subjects before and after therapy, and in a group of healthy controls. Before LSVT, patients had strong speechrelated activations in motor and premotor cortex, supplementary motor cortex and inferior lateral premotor cortex which were significantly reduced post-LSVT. In addition, significant right-sided activations were present in anterior insular cortex, caudate head, putamen, and dorsolateral prefrontal cortex following LSVT. Finally, the LSVT-induced neural changes were not present with transient experimentercued increases of loudness in LSVT-untreated patients. This treatment-dependant functional reorganization suggests a shift from an abnormally effortful to a more automatic implementation of speech-motor actions.

Original languageEnglish (US)
Title of host publication7th International Conference on Spoken Language Processing, ICSLP 2002
PublisherInternational Speech Communication Association
Pages2477-2480
Number of pages4
StatePublished - 2002
Event7th International Conference on Spoken Language Processing, ICSLP 2002 - Denver, United States
Duration: Sep 16 2002Sep 20 2002

Other

Other7th International Conference on Spoken Language Processing, ICSLP 2002
CountryUnited States
CityDenver
Period9/16/029/20/02

Fingerprint

activation
Disease
reorganization
present
Group
Parkinson's Disease
Positron Emission Tomography
Neural Correlates
Cortex

ASJC Scopus subject areas

  • Language and Linguistics
  • Linguistics and Language

Cite this

Liotti, M., Ramig, L., Vogel, D., New, P., Cook, C., & Fox, P. T. (2002). Hypophonia in Parkinson disease: Neural correlates of voice treatment with LSVT revealed by PET. In 7th International Conference on Spoken Language Processing, ICSLP 2002 (pp. 2477-2480). International Speech Communication Association.

Hypophonia in Parkinson disease : Neural correlates of voice treatment with LSVT revealed by PET. / Liotti, Mario; Ramig, Lorraine; Vogel, Deanie; New, Pamela; Cook, Chris; Fox, Peter T.

7th International Conference on Spoken Language Processing, ICSLP 2002. International Speech Communication Association, 2002. p. 2477-2480.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Liotti, M, Ramig, L, Vogel, D, New, P, Cook, C & Fox, PT 2002, Hypophonia in Parkinson disease: Neural correlates of voice treatment with LSVT revealed by PET. in 7th International Conference on Spoken Language Processing, ICSLP 2002. International Speech Communication Association, pp. 2477-2480, 7th International Conference on Spoken Language Processing, ICSLP 2002, Denver, United States, 9/16/02.
Liotti M, Ramig L, Vogel D, New P, Cook C, Fox PT. Hypophonia in Parkinson disease: Neural correlates of voice treatment with LSVT revealed by PET. In 7th International Conference on Spoken Language Processing, ICSLP 2002. International Speech Communication Association. 2002. p. 2477-2480
Liotti, Mario ; Ramig, Lorraine ; Vogel, Deanie ; New, Pamela ; Cook, Chris ; Fox, Peter T. / Hypophonia in Parkinson disease : Neural correlates of voice treatment with LSVT revealed by PET. 7th International Conference on Spoken Language Processing, ICSLP 2002. International Speech Communication Association, 2002. pp. 2477-2480
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