Abstract
Insulin-induced hypoglycemia has long represented a troublesome complication in the treatment of diabetes mellitus. This problem has recently gained special significance, as efforts to normalize glycemia in type I diabetics have become increasingly aggressive. With these more vigorous attempts to achieve meticulous metabolic control, and their attendant risk of hypoglycemia, interest has been rekindled in the physiologic mechanisms subserving hypoglycemic counterregulation and how these mechanisms are altered in the insulin-treated diabetic. This review summarizes our current understanding of glucose counterregulation in normal man, with particular emphasis on the important differences observed in patients with type I diabetes.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 84-93 |
| Number of pages | 10 |
| Journal | Annals of Clinical Research |
| Volume | 16 |
| Issue number | 2 |
| State | Published - 1984 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Medicine(all)
Cite this
Hypoglycemic counterregulation in normal and diabetic man. / Gelfand, R. A.; Defronzo, Ralph A.
In: Annals of Clinical Research, Vol. 16, No. 2, 1984, p. 84-93.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Hypoglycemic counterregulation in normal and diabetic man
AU - Gelfand, R. A.
AU - Defronzo, Ralph A
PY - 1984
Y1 - 1984
N2 - Insulin-induced hypoglycemia has long represented a troublesome complication in the treatment of diabetes mellitus. This problem has recently gained special significance, as efforts to normalize glycemia in type I diabetics have become increasingly aggressive. With these more vigorous attempts to achieve meticulous metabolic control, and their attendant risk of hypoglycemia, interest has been rekindled in the physiologic mechanisms subserving hypoglycemic counterregulation and how these mechanisms are altered in the insulin-treated diabetic. This review summarizes our current understanding of glucose counterregulation in normal man, with particular emphasis on the important differences observed in patients with type I diabetes.
AB - Insulin-induced hypoglycemia has long represented a troublesome complication in the treatment of diabetes mellitus. This problem has recently gained special significance, as efforts to normalize glycemia in type I diabetics have become increasingly aggressive. With these more vigorous attempts to achieve meticulous metabolic control, and their attendant risk of hypoglycemia, interest has been rekindled in the physiologic mechanisms subserving hypoglycemic counterregulation and how these mechanisms are altered in the insulin-treated diabetic. This review summarizes our current understanding of glucose counterregulation in normal man, with particular emphasis on the important differences observed in patients with type I diabetes.
UR - http://www.scopus.com/inward/record.url?scp=0021153927&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0021153927&partnerID=8YFLogxK
M3 - Article
VL - 16
SP - 84
EP - 93
JO - Annals of Medicine
JF - Annals of Medicine
SN - 0785-3890
IS - 2
ER -