Hypertension in Pheochromocytoma and Paraganglioma: Evaluation and Management in Pediatric Patients

Meredith L. Seamon, Ikuyo Yamaguchi

Research output: Contribution to journalReview articlepeer-review


Purpose of Review: The rare catecholamine-secreting tumors, pheochromocytomas and paragangliomas (PPGL), account for a minority of cases of secondary hypertension in pediatrics. As such, perioperative blood pressure (BP) management in pediatric patients presents a distinct challenge. This review will expand the practitioner’s knowledge of antihypertensive treatment options for the pediatric patient with PPGL with a focus on literature in the past several years. Recent Findings: There continue to be only small case series and single-center experiences to provide guidelines regarding BP management. While phenoxybenzamine has been more routinely used, selective α1-blockers, such as doxazosin, as well as calcium channel blockers, have also been utilized with success in pediatric patients. Summary: While the concept of obligatory α-adrenergic blockade for adult patients has been recently challenged, international guidelines and current practice patterns among pediatric clinicians continue to support preoperative α-adrenergic blockade to ensure the best possible patient outcomes. Selective α1-blockers and calcium channel blockers are becoming more commonly used given the high cost, limited availability, and undesirable side effect profile of phenoxybenzamine.

Original languageEnglish (US)
Article number32
JournalCurrent Hypertension Reports
Issue number5
StatePublished - May 2021
Externally publishedYes


  • Amlodipine
  • Doxazosin
  • Hypertension
  • Paragangliomas (PGL)
  • Pediatrics
  • Pheochromocytomas (PCC)

ASJC Scopus subject areas

  • Internal Medicine


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