Hypertension impairs neurovascular coupling and promotes microvascular injury: role in exacerbation of Alzheimer’s disease

Anna Csiszar, Stefano Tarantini, Gábor A. Fülöp, Tamas Kiss, M. Noa Valcarcel-Ares, Veronica Galvan, Zoltan Ungvari, Andriy Yabluchanskiy

Research output: Contribution to journalArticlepeer-review

45 Scopus citations

Abstract

Hypertension in the elderly substantially increases both the risk of vascular cognitive impairment (VCI) and Alzheimer’s disease (AD); however, the underlying mechanisms are not completely understood. This review discusses the effects of hypertension on structural and functional integrity of cerebral microcirculation, including hypertension-induced alterations in neurovascular coupling responses, cellular and molecular mechanisms involved in microvascular damage (capillary rarefaction, blood-brain barrier disruption), and the genesis of cerebral microhemorrhages and their potential role in exacerbation of cognitive decline associated with AD. Understanding and targeting the hypertension-induced cerebromicrovascular alterations that are involved in the onset and progression of AD and contribute to cognitive impairment are expected to have a major role in preserving brain health in high-risk older individuals.

Original languageEnglish (US)
Pages (from-to)359-372
Number of pages14
JournalGeroScience
Volume39
Issue number4
DOIs
StatePublished - Aug 1 2017

Keywords

  • Alzheimer’s disease
  • Angiotensin II
  • Endothelial dysfunction
  • Functional hyperemia
  • High blood pressure
  • Hypertension
  • Microcirculation
  • Neurovascular coupling
  • VCID

ASJC Scopus subject areas

  • Aging
  • Geriatrics and Gerontology

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