Hypertension and intracerebral hemorrhage recurrence among white, black, and hispanic individuals

Axana Rodriguez-Torres, Meredith Murphy, Christina Kourkoulis, Kristin Schwab, Alison M. Ayres, Charles J. Moomaw, Soo Young Kwon, Jimmy V. Berthaud, M. Edip Gurol, Steven M. Greenberg, Anand Viswanathan, Christopher D. Anderson, Matthew Flaherty, Michael L. James, Lee Birnbaum, Gene Yong Sung, Gunjan Parikh, Amelia K. Boehme, Douglas Mayson, Kevin N. ShethChelsea Kidwell, Sebastian Koch, Michael Frankel, Carl D. Langefeld, Fernando D. Testai, Daniel Woo, Jonathan Rosand, Alessandro Biffi

Research output: Contribution to journalArticlepeer-review

28 Scopus citations


Objective To clarify whether recurrence risk for intracerebral hemorrhage (ICH) is higher among black and Hispanic individuals and whether this disparity is attributable to differences in blood pressure (BP) measurements and their variability. Methods We analyzed data from survivors of primary ICH enrolled in 2 separate studies: (1) the longitudinal study conducted at Massachusetts General Hospital (n = 759), and (2) the ERICH (Ethnic/Racial Variations of Intracerebral Hemorrhage) study (n = 1,532). Participants underwent structured interview at enrollment (including self-report of race/ethnicity) and were followed longitudinally via phone calls and review of medical records. We captured systolic BP (SBP) and diastolic BP measurements, and quantified variability as SBP and diastolic BP variation coefficients. We used multivariable (Cox regression) survival analysis to identify risk factors for ICH recurrence. Results We followed 2,291 ICH survivors (1,121 white, 529 black, 605 Hispanic, and 36 of other race/ ethnicity). Both black and Hispanic patients displayed higher SBP during follow-up (p < 0.05). Black participants also displayed greater SBP variability during follow-up (p = 0.032). In univariable analyses, black and Hispanic patients were at higher ICH recurrence risk (p < 0.05). After adjusting for BP measurements and their variability, both Hispanic (hazard ratio = 1.51, 95% confidence interval 1.14-2.00, p = 0.004) and black (hazard ratio = 1.98, 95% confidence interval 1.36-2.86, p < 0.001) patients remained at higher risk of ICH recurrence. Conclusion Black and Hispanic patients are at higher risk of ICH recurrence; hypertension severity (average BP and its variability) does not fully account for this finding. Additional studies will be required to further elucidate determinants for this health disparity.

Original languageEnglish (US)
Pages (from-to)E37-E44
Issue number1
StatePublished - Jul 3 2018

ASJC Scopus subject areas

  • Clinical Neurology


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