Hypernatremic State in Hypermetabolic Burn Patients

Glenn D. Warden, Douglas W. Wilmore, Philip W. Rogers, Arthur D. Mason, Basil A. Pruitt

Research output: Contribution to journalArticlepeer-review

24 Scopus citations


Fifty-one patients treated during the past 18 months, representing a total of 10.9% of the admissions to the burn unit, developed hypernatremia, with a serum sodium level above 145 mEq/liter; 60.8% of the patients had inadequate replacement of insensible fluid losses, and 31.3% of the cases developed hypernatremia during septic states. A small group of patients developed hypernatremia secondary to a solute diuresis with uncontrolled diabetes mellitus or supranormal caloric feedings. Two patients were identified with an apparent derangement in the antidiuretic hormone mechanism, and were treated by the administration of vasopressin injection (Pitressin). Clinical assessment, serial body weights, accurate fluid intake and output records, and laboratory monitoring are essential to the diagnosis and treatment of the hypernatremic state in hypermetabolic burn patients.

Original languageEnglish (US)
Pages (from-to)420-427
Number of pages8
JournalArchives of Surgery
Issue number4
StatePublished - Apr 1973
Externally publishedYes

ASJC Scopus subject areas

  • Surgery


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