Hypermethylation of ribosomal DNA in human breast carcinoma

P. S. Yan, F. J. Rodriguez, D. E. Laux, M. R. Perry, S. B. Standiford, Hui-ming Huang

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

We examined the methylation status of the transcribed domain of ribosomal DNA (rDNA) in 58 patients with breast cancer. The mean percent of methylation was significantly higher in breast tumours than that of normal control samples (P < 0.0001). This increased rDNA methylation was associated with oestrogen receptor non-expression (P < 0.0273) and with moderately or poorly differentiated tumours as compared to well differentiated tumours (P < 0.0475). Our results suggest that rDNA can be a useful marker for monitoring aberrant methylation during breast tumour progression. (C) 2000 Cancer Research Campaign.

Original languageEnglish (US)
Pages (from-to)514-517
Number of pages4
JournalBritish Journal of Cancer
Volume82
Issue number3
StatePublished - 2000
Externally publishedYes

Fingerprint

Ribosomal DNA
Methylation
Breast Neoplasms
DNA Methylation
Estrogen Receptors
Neoplasms

Keywords

  • Breast cancer
  • DNA hypermethylation
  • Ribosomal DNA

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Yan, P. S., Rodriguez, F. J., Laux, D. E., Perry, M. R., Standiford, S. B., & Huang, H. (2000). Hypermethylation of ribosomal DNA in human breast carcinoma. British Journal of Cancer, 82(3), 514-517.

Hypermethylation of ribosomal DNA in human breast carcinoma. / Yan, P. S.; Rodriguez, F. J.; Laux, D. E.; Perry, M. R.; Standiford, S. B.; Huang, Hui-ming.

In: British Journal of Cancer, Vol. 82, No. 3, 2000, p. 514-517.

Research output: Contribution to journalArticle

Yan, PS, Rodriguez, FJ, Laux, DE, Perry, MR, Standiford, SB & Huang, H 2000, 'Hypermethylation of ribosomal DNA in human breast carcinoma', British Journal of Cancer, vol. 82, no. 3, pp. 514-517.
Yan PS, Rodriguez FJ, Laux DE, Perry MR, Standiford SB, Huang H. Hypermethylation of ribosomal DNA in human breast carcinoma. British Journal of Cancer. 2000;82(3):514-517.
Yan, P. S. ; Rodriguez, F. J. ; Laux, D. E. ; Perry, M. R. ; Standiford, S. B. ; Huang, Hui-ming. / Hypermethylation of ribosomal DNA in human breast carcinoma. In: British Journal of Cancer. 2000 ; Vol. 82, No. 3. pp. 514-517.
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