Hypermethylation of ribosomal DNA in human breast carcinoma

P. S. Yan, F. J. Rodriguez, D. E. Laux, M. R. Perry, S. B. Standiford, T. H.M. Huang

Research output: Contribution to journalArticlepeer-review

26 Scopus citations

Abstract

We examined the methylation status of the transcribed domain of ribosomal DNA (rDNA) in 58 patients with breast cancer. The mean percent of methylation was significantly higher in breast tumours than that of normal control samples (P < 0.0001). This increased rDNA methylation was associated with oestrogen receptor non-expression (P < 0.0273) and with moderately or poorly differentiated tumours as compared to well differentiated tumours (P < 0.0475). Our results suggest that rDNA can be a useful marker for monitoring aberrant methylation during breast tumour progression. (C) 2000 Cancer Research Campaign.

Original languageEnglish (US)
Pages (from-to)514-517
Number of pages4
JournalBritish Journal of Cancer
Volume82
Issue number3
DOIs
StatePublished - 2000

Keywords

  • Breast cancer
  • DNA hypermethylation
  • Ribosomal DNA

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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