Hypermethylation of ribosomal DNA in human breast carcinoma

P. S. Yan; F. J. Rodriguez; D. E. Laux; M. R. Perry; S. B. Standiford; T. H.M. Huang

doi:10.1054/bjoc.1999.0955

Hypermethylation of ribosomal DNA in human breast carcinoma

P. S. Yan, F. J. Rodriguez, D. E. Laux, M. R. Perry, S. B. Standiford, T. H.M. Huang

Research output: Contribution to journal › Article › peer-review

33 Scopus citations

Abstract

We examined the methylation status of the transcribed domain of ribosomal DNA (rDNA) in 58 patients with breast cancer. The mean percent of methylation was significantly higher in breast tumours than that of normal control samples (P < 0.0001). This increased rDNA methylation was associated with oestrogen receptor non-expression (P < 0.0273) and with moderately or poorly differentiated tumours as compared to well differentiated tumours (P < 0.0475). Our results suggest that rDNA can be a useful marker for monitoring aberrant methylation during breast tumour progression. (C) 2000 Cancer Research Campaign.

Original language	English (US)
Pages (from-to)	514-517
Number of pages	4
Journal	British Journal of Cancer
Volume	82
Issue number	3
DOIs	https://doi.org/10.1054/bjoc.1999.0955
State	Published - 2000
Externally published	Yes

Keywords

Breast cancer
DNA hypermethylation
Ribosomal DNA

ASJC Scopus subject areas

Oncology
Cancer Research

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10.1054/bjoc.1999.0955

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title = "Hypermethylation of ribosomal DNA in human breast carcinoma",

abstract = "We examined the methylation status of the transcribed domain of ribosomal DNA (rDNA) in 58 patients with breast cancer. The mean percent of methylation was significantly higher in breast tumours than that of normal control samples (P < 0.0001). This increased rDNA methylation was associated with oestrogen receptor non-expression (P < 0.0273) and with moderately or poorly differentiated tumours as compared to well differentiated tumours (P < 0.0475). Our results suggest that rDNA can be a useful marker for monitoring aberrant methylation during breast tumour progression. (C) 2000 Cancer Research Campaign.",

keywords = "Breast cancer, DNA hypermethylation, Ribosomal DNA",

author = "Yan, {P. S.} and Rodriguez, {F. J.} and Laux, {D. E.} and Perry, {M. R.} and Standiford, {S. B.} and Huang, {T. H.M.}",

note = "Funding Information: The authors wish to thank Professor Adrian Bird at the University of Edinburgh for providing plasmids pHsrDNA5.1 and pHsrDNA7.9. This work was supported by National Cancer Institute grant CA-69065 (TH-MH) and by US Army Medical Research Command grant DAMD17-98-1-8214 (TH-MH).",

year = "2000",

doi = "10.1054/bjoc.1999.0955",

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AU - Rodriguez, F. J.

AU - Laux, D. E.

AU - Perry, M. R.

AU - Standiford, S. B.

AU - Huang, T. H.M.

N1 - Funding Information: The authors wish to thank Professor Adrian Bird at the University of Edinburgh for providing plasmids pHsrDNA5.1 and pHsrDNA7.9. This work was supported by National Cancer Institute grant CA-69065 (TH-MH) and by US Army Medical Research Command grant DAMD17-98-1-8214 (TH-MH).

PY - 2000

Y1 - 2000

N2 - We examined the methylation status of the transcribed domain of ribosomal DNA (rDNA) in 58 patients with breast cancer. The mean percent of methylation was significantly higher in breast tumours than that of normal control samples (P < 0.0001). This increased rDNA methylation was associated with oestrogen receptor non-expression (P < 0.0273) and with moderately or poorly differentiated tumours as compared to well differentiated tumours (P < 0.0475). Our results suggest that rDNA can be a useful marker for monitoring aberrant methylation during breast tumour progression. (C) 2000 Cancer Research Campaign.

AB - We examined the methylation status of the transcribed domain of ribosomal DNA (rDNA) in 58 patients with breast cancer. The mean percent of methylation was significantly higher in breast tumours than that of normal control samples (P < 0.0001). This increased rDNA methylation was associated with oestrogen receptor non-expression (P < 0.0273) and with moderately or poorly differentiated tumours as compared to well differentiated tumours (P < 0.0475). Our results suggest that rDNA can be a useful marker for monitoring aberrant methylation during breast tumour progression. (C) 2000 Cancer Research Campaign.

KW - Breast cancer

KW - DNA hypermethylation

KW - Ribosomal DNA

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Hypermethylation of ribosomal DNA in human breast carcinoma

Abstract

Keywords

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