Hyperinsulinemia in a population at high risk for non-insulin-dependent diabetes mellitus

S. M. Haffner, M. P. Stern, Helen P Hazuda, Jacqueline A Pugh, J. K. Patterson

Research output: Contribution to journalArticle

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Abstract

The prevalence of non-insulin-dependent diabetes mellitus (NIDDM) is higher in Mexican Americans than in non-Hispanic white Americans, even after adjustment for the former's greater overall and more centralized adiposity. We postulated that this excess risk of NIDDM could be due to resistance to insulin. We performed oral glucose-tolerance tests with measurements of serum insulin concentrations in 225 Mexican Americans and 180 non-Hispanic whites without diabetes as part of the San Antonio Heart Study, a population-based study of risk factors for diabetes. Changes in serum insulin concentrations in response to the glucose challenge were quantified by the area under the serum insulin curve. Overall adiposity was characterized by body-mass index, and regional body-fat distribution by the ratio of subscapular to triceps skinfolds and the ratio of waist to hip circumference. After adjustment for these indicators of adiposity and also for differences in glucose tolerance. Mexican Americans were found to have significantly greater areas under the serum insulin curve than non-Hispanic whites. These data suggest that, like other populations at high risk for NIDDM such as Pima Indians and Micronesians, Mexican Americans have more hyperinsulinemia that can be accounted for by their adiposity.

Original languageEnglish (US)
Pages (from-to)220-224
Number of pages5
JournalNew England Journal of Medicine
Volume315
Issue number4
StatePublished - 1986

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Adiposity
Hyperinsulinism
Type 2 Diabetes Mellitus
Insulin
Serum
Body Fat Distribution
Potassium Iodide
Glucose
Waist-Hip Ratio
Glucose Tolerance Test
Insulin Resistance
Body Mass Index
Population

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Haffner, S. M., Stern, M. P., Hazuda, H. P., Pugh, J. A., & Patterson, J. K. (1986). Hyperinsulinemia in a population at high risk for non-insulin-dependent diabetes mellitus. New England Journal of Medicine, 315(4), 220-224.

Hyperinsulinemia in a population at high risk for non-insulin-dependent diabetes mellitus. / Haffner, S. M.; Stern, M. P.; Hazuda, Helen P; Pugh, Jacqueline A; Patterson, J. K.

In: New England Journal of Medicine, Vol. 315, No. 4, 1986, p. 220-224.

Research output: Contribution to journalArticle

Haffner, SM, Stern, MP, Hazuda, HP, Pugh, JA & Patterson, JK 1986, 'Hyperinsulinemia in a population at high risk for non-insulin-dependent diabetes mellitus', New England Journal of Medicine, vol. 315, no. 4, pp. 220-224.
Haffner SM, Stern MP, Hazuda HP, Pugh JA, Patterson JK. Hyperinsulinemia in a population at high risk for non-insulin-dependent diabetes mellitus. New England Journal of Medicine. 1986;315(4):220-224.
Haffner, S. M. ; Stern, M. P. ; Hazuda, Helen P ; Pugh, Jacqueline A ; Patterson, J. K. / Hyperinsulinemia in a population at high risk for non-insulin-dependent diabetes mellitus. In: New England Journal of Medicine. 1986 ; Vol. 315, No. 4. pp. 220-224.
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