Hyperinsulinemia and Non-Insulin-Dependent Diabetes Mellitus

Richard J. Mahler, Steven M. Haffner, Jacqueline A. Pugh, Michael P. Stern, Judith K. Patterson

Research output: Contribution to journalLetterpeer-review

2 Scopus citations


To the Editor: In discussing the presence of greater hyperinsulinemia among Mexican-Americans as compared with non-Hispanic whites, Haffner et al. (July 24 issue)1 state that this “reflects the inclusion in the former group of a larger proportion of future diabetics who have compensatory hypersecretion of insulin secondary to increased insulin resistance and, as a result, are at increased risk for eventual islet-cell decompensation.” First, there are no data supporting the hypothesis that insulin hypersecretion is secondary to insulin resistance. In fact, when Szabo and I reduced insulin hypersecretion to normal by pharmacologic means in obese hyperglycemic animals, there was a….

Original languageEnglish (US)
Pages (from-to)110-111
Number of pages2
JournalNew England Journal of Medicine
Issue number2
StatePublished - Jan 8 1987
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)


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