Hyperglycemia-related pathophysiologic mechanisms and potential beneficial actions of melatonin

Ahmet Korkmaz, Turgut Topal, Sukru Oter, Dun Xian Tan, Russel J. Reiter

Research output: Contribution to journalArticlepeer-review

16 Scopus citations

Abstract

Chronically-elevated blood glucose initiates a harmful series of processes in which toxic reactive species play crucial roles. Oxidative as well as nitro-oxidative stress is harmful for virtually all biomolecules including lipids, proteins and DNA. Such pathophysiologic mechanisms eventually results in cellular dysfunction, apoptosis or necrosis. Melatonin is a multifunctional indolamine which counteracts several pathophysiologic steps and displays significant beneficial effects against hyperglycemia-induced cellular toxicity. These are related to melatonin's antioxidative, anti-inflammatory and possibly epigenetic regulatory properties. Current knowledge encourages using this non-toxic indolamine either as a sole treatment or in conjunction with other treatments for inhibition of the biohazards of hyperglycemia.

Original languageEnglish (US)
Pages (from-to)1144-1153
Number of pages10
JournalMini-Reviews in Medicinal Chemistry
Volume8
Issue number11
DOIs
StatePublished - Dec 10 2008

Keywords

  • DNA damage
  • Free radicals
  • Hyperglycemia
  • Melatonin
  • Peroxynitrite

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmacology
  • Drug Discovery
  • Cancer Research

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