Hydra, a powerful model for aging studies

Szymon Tomczyk, Kathleen Fischer, Steven Austad, Brigitte Galliot

Research output: Contribution to journalReview articlepeer-review

36 Scopus citations


Cnidarian Hydra polyps escape senescence, most likely due to the robust activity of their three stem cell populations. These stem cells continuously self-renew in the body column and differentiate at the extremities following a tightly coordinated spatial pattern. Paul Brien showed in 1953 that in one particular species, Hydra oligactis, cold-dependent sexual differentiation leads to rapid aging and death. Here, we review the features of this inducible aging phenotype. These cellular alterations, detected several weeks after aging was induced, are characterized by a decreasing density of somatic interstitial cell derivatives, a disorganization of the apical nervous system, and a disorganization of myofibers of the epithelial cells. Consequently, tissue replacement required to maintain homeostasis, feeding behavior, and contractility of the animal are dramatically affected. Interestingly, this aging phenotype is not observed in all H. oligactis strains, thus providing a powerful experimental model for investigations of the genetic control of aging. Given the presence in the cnidarian genome of a large number of human orthologs that have been lost in ecdysozoans, such approaches might help uncover novel regulators of aging in vertebrates.

Original languageEnglish (US)
Pages (from-to)11-16
Number of pages6
JournalInvertebrate Reproduction and Development
StatePublished - Jan 30 2015


  • Cold-sensitive strain
  • Hydra oligactis
  • inducible aging
  • loss of somatic stem cells
  • neurodegeneration
  • sexual differentiation

ASJC Scopus subject areas

  • Animal Science and Zoology
  • Developmental Biology


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