Hybrid fibrillation potentials and positive sharp waves

Daniel Dumitru, John C. King

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

Fibrillation potential configurations are characterized as initially positive triphasic waveforms, whereas positive sharp waves appear biphasic with an initial positive deflection. Careful observation of single muscle fiber discharges in denervated muscle, however, can reveal many different-appearing and stable firing waveforms that resemble a bifid positive sharp wave or some form of combined fibrillation potential and positive sharp wave. In this investigation, a number of atypical-appearing single muscle fiber discharges are hypothesized to arise from particular interactions between the muscle fiber and recording electrode. Single muscle fiber potentials are modeled as originating from a single denervated muscle fiber's former endplate and midfiber region as well as from the fiber's tendinous termination for both a compressed and sealed end effect. The modeled waveforms' appearance corresponds well to those obtained clinically and the necessary interpotential summated templates' temporal domains are feasible for action potential termination at the electrode with subsequent reinitiation beyond the proposed peri-electrode compressed region. It is hypothesized that the majority of hybrid waveforms are the result of a single muscle fiber action potential terminating at a recording electrode while also initiating a 'skipped' activation of the muscle fiber past the electrode resulting in the summation of two distinct time-locked waveforms. (C) 2000 John Wiley and Sons, Inc.

Original languageEnglish (US)
Pages (from-to)1234-1242
Number of pages9
JournalMuscle and Nerve
Volume23
Issue number8
DOIs
StatePublished - Aug 1 2000

Keywords

  • Computer modeling
  • Fibrillation potential
  • Needle electromyography
  • Positive sharp wave
  • Volume conduction

ASJC Scopus subject areas

  • Physiology
  • Clinical Neurology
  • Cellular and Molecular Neuroscience
  • Physiology (medical)

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