Hyaluronic acid in the evaluation of liver fibrosis in patients with hepatitis C on haemodialysis

Renata Eliane de Ávila, Ricardo Andrade Carmo, Kátia Paula de Farah, Antônio Lúcio Teixeira, Lucas Viana Coimbra, Carlos Maurício Figueiredo de Antunes, José Roberto Lambertucci

Research output: Contribution to journalArticlepeer-review

12 Scopus citations

Abstract

Background: This study evaluated the role of HA as a marker of liver fibrosis in patients with hepatitis C on haemodialysis. Methods: This is a cross-sectional study in which 52 patients were divided into two groups: Group 1: patients with hepatitis C and end-stage renal disease (ESRD) undergoing haemodialysis (n = 23); and Group 2: patients with hepatitis C without ESRD (n = 29). Plasma levels of HA were associated with histological data of the samples obtained by liver biopsy and classified by METAVIR group scoring system. Results: Higher plasma levels were significantly correlated to significant liver fibrosis (METAVIR ≥ F2). In Group 1, the HA cutoff to discriminate significant fibrosis was 984.8 ng/mL, with accuracy, sensitivity and specificity of 80.8%, 83.0%, and 70.0%, respectively. In Group 2, the HA cutoff was 222.3 ng/mL, with accuracy, sensitivity and specificity of 74.5%, 70.0%, and 94.0%, respectively. Conclusion: HA was an accurate noninvasive marker in predicting significant fibrosis in patients with hepatitis C on haemodialysis.

Original languageEnglish (US)
Pages (from-to)335-341
Number of pages7
JournalBrazilian Journal of Infectious Diseases
Volume14
Issue number4
DOIs
StatePublished - 2010
Externally publishedYes

Keywords

  • End-stage renal disease
  • Haemodialysis
  • Hepatitis C
  • Hyaluronic acid

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases

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