TY - JOUR
T1 - Humoral immune response to thymidylate synthase in colon cancer patients after 5-FU chemotherapy
AU - Shebzukhov, Yuriy V.
AU - Koroleva, Ekaterina P.
AU - Khlgatian, Svetlana V.
AU - Lagarkova, Maria A.
AU - Meshcheryakov, Andrey A.
AU - Lichinitser, Mikhail R.
AU - Karbach, Julia
AU - Jager, Elke
AU - Kuprash, Dmitry V.
AU - Nedospasov, Sergei A.
N1 - Funding Information:
Work in Moscow was supported by the Ludwig Institute for Cancer Research, Cancer Antigen Discovery Collaborative of the Cancer Research Institute, by Molecular and Cellular Biology Program of the Russian Academy of Sciences and by Russian Foundation for Basic Research (grant 05-04-49075-a). Work at Frederick was funded in part with Federal funds from National Cancer Institute, National Institutes of Health, under Contract # N01-CO-12400.
PY - 2005/8/15
Y1 - 2005/8/15
N2 - Thymidylate synthase (TYMS), the critical enzyme for DNA synthesis and a target for chemotherapy, was recently characterized as an oncogene and a potential target for specific immunotherapy. Here we report TYMS-specific antibody response in a fraction of colon cancer patients. Humoral immune response to TYMS is induced by chemotherapy using TYMS inhibitors, such as 5-fluorouracil (5-FU), and may be associated with tumor burden. Therefore, TYMS may serve as a useful serological biomarker for monitoring the course of disease and treatment in cancer patients.
AB - Thymidylate synthase (TYMS), the critical enzyme for DNA synthesis and a target for chemotherapy, was recently characterized as an oncogene and a potential target for specific immunotherapy. Here we report TYMS-specific antibody response in a fraction of colon cancer patients. Humoral immune response to TYMS is induced by chemotherapy using TYMS inhibitors, such as 5-fluorouracil (5-FU), and may be associated with tumor burden. Therefore, TYMS may serve as a useful serological biomarker for monitoring the course of disease and treatment in cancer patients.
KW - 5-Fluorouracil (5-FU)
KW - Antibodies
KW - Serology
KW - Thymidylate synthase (TYMS)
UR - https://www.scopus.com/pages/publications/24344498714
UR - https://www.scopus.com/pages/publications/24344498714#tab=citedBy
U2 - 10.1016/j.imlet.2005.06.011
DO - 10.1016/j.imlet.2005.06.011
M3 - Article
C2 - 16055198
AN - SCOPUS:24344498714
SN - 0165-2478
VL - 100
SP - 88
EP - 93
JO - Immunology Letters
JF - Immunology Letters
IS - 1
ER -