Human variants of O6-alkylguanine-DNA alkyltransferase

Anthony E. Pegg, Qingming Fang, Natalia A. Loktionova

Research output: Contribution to journalReview articlepeer-review

59 Scopus citations


This article summarizes the current understanding of known variant forms of the MGMT gene that encode an altered protein. Epidemiological studies have been carried out to test whether these alterations are associated with altered cancer risk. Laboratory studies using recombinant proteins and cells expressing the known variants have investigated the possible effects of these sequence alterations on the ability of the encoded O6-alkylguanine-DNA alkyltransferase protein to protect cells from alkylation damage and to respond to therapeutic inactivators currently undergoing trials for cancer chemotherapy.

Original languageEnglish (US)
Pages (from-to)1071-1078
Number of pages8
JournalDNA Repair
Issue number8
StatePublished - Aug 1 2007
Externally publishedYes


  • Inactivator
  • O-Alkylguanine-DNA alkyltransferase
  • Variant

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology


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