Human studies with the chelating agents, DMPS and DMSA

H. Vasken Aposhian, Richard M. Maiorino, Mario Rivera, David C. Bruce, Richard C. Dart, Katherine M. Hurlbut, Deborah J Levine, Wei Zheng, Quintus Fernando, Dean Carter, Mary M. Aposhian

Research output: Contribution to journalArticle

104 Citations (Scopus)

Abstract

Meso-2,3-dimercaptosuccinic acid (DMSA) is bound to plasma albumin in humans and appears to be excreted in the urine as the DMSA-cysteine mixed disulfide. The pharmacokinetics of DMSA have been determined after its administration to humans po. For the blood, the tmaxand tl/2 were 3.0 h + 0.45 SE and 3.2 h + 0.56 SE, respectively. The Cmax was 26.2 μM + 4.7 SE. To determine whether dental amalgams influence the human body burden of mercury, we gave volunteers the sodium salt of 2,3-dimer-captopropane-1-sulfonic acid (DMPS). The diameters of dental amalgams of the subjects were determined to obtain the amalgam score. Administration of 300 mg DMPS by mouth increased the mean urinary mercury excretion of subjects over a 9 h period. There was a positive correlation between the amount of mercury excreted and the amalgam score. DMPS might be useful for increasing the urinary excretion of mercury and thus increasing the significance and reliability of this measure of mercury exposure. DMSA analogs have been designed and synthesized in attempts to increase the uptake by cell membranes of the DMSA prototype chelating agents. The iv administration of the monomethyl ester of DMSA, the dimethyl ester of DMSA or the zinc chelate of dimethyl DMSA increases the biliary excretion of platinum and cadmium in rats.

Original languageEnglish (US)
Pages (from-to)505-528
Number of pages24
JournalClinical Toxicology
Volume30
Issue number4
DOIs
StatePublished - 1992
Externally publishedYes

Fingerprint

Succimer
Sulfonic Acids
Chelating Agents
Dimers
Mercury
Dental Amalgam
Mercury amalgams
Body Burden
Pharmacokinetics
Cell membranes
Platinum
Cadmium
Human Body
Serum Albumin
Disulfides
Cysteine
Mouth
Zinc
Rats
Volunteers

Keywords

  • Chelating agents
  • Pharmacokinetics, human
  • Poisoning, human

ASJC Scopus subject areas

  • Toxicology
  • Health, Toxicology and Mutagenesis

Cite this

Vasken Aposhian, H., Maiorino, R. M., Rivera, M., Bruce, D. C., Dart, R. C., Hurlbut, K. M., ... Aposhian, M. M. (1992). Human studies with the chelating agents, DMPS and DMSA. Clinical Toxicology, 30(4), 505-528. https://doi.org/10.3109/15563659209017938

Human studies with the chelating agents, DMPS and DMSA. / Vasken Aposhian, H.; Maiorino, Richard M.; Rivera, Mario; Bruce, David C.; Dart, Richard C.; Hurlbut, Katherine M.; Levine, Deborah J; Zheng, Wei; Fernando, Quintus; Carter, Dean; Aposhian, Mary M.

In: Clinical Toxicology, Vol. 30, No. 4, 1992, p. 505-528.

Research output: Contribution to journalArticle

Vasken Aposhian, H, Maiorino, RM, Rivera, M, Bruce, DC, Dart, RC, Hurlbut, KM, Levine, DJ, Zheng, W, Fernando, Q, Carter, D & Aposhian, MM 1992, 'Human studies with the chelating agents, DMPS and DMSA', Clinical Toxicology, vol. 30, no. 4, pp. 505-528. https://doi.org/10.3109/15563659209017938
Vasken Aposhian H, Maiorino RM, Rivera M, Bruce DC, Dart RC, Hurlbut KM et al. Human studies with the chelating agents, DMPS and DMSA. Clinical Toxicology. 1992;30(4):505-528. https://doi.org/10.3109/15563659209017938
Vasken Aposhian, H. ; Maiorino, Richard M. ; Rivera, Mario ; Bruce, David C. ; Dart, Richard C. ; Hurlbut, Katherine M. ; Levine, Deborah J ; Zheng, Wei ; Fernando, Quintus ; Carter, Dean ; Aposhian, Mary M. / Human studies with the chelating agents, DMPS and DMSA. In: Clinical Toxicology. 1992 ; Vol. 30, No. 4. pp. 505-528.
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