Human platelet stimulation by acetyl glyceryl ether phosphorylcholine

L. M. McManus; D. J. Hanahan; R. N. Pinckard

doi:10.1172/JCI110108

Human platelet stimulation by acetyl glyceryl ether phosphorylcholine

L. M. McManus, D. J. Hanahan, R. N. Pinckard

Department of Pathology

Research output: Contribution to journal › Article › peer-review

139 Scopus citations

Abstract

Acetyl glyceryl ether phosphorylcholine (AGEPC) induced dose-dependent platelet aggregation and release of [³H]serotonin and platelet factor 4 in citrated human platelet-rich plasma. ADP scavengers or indomethacin prevented irreversible platelet aggregation responses induced by 0.2 μM AGEPC but had no effect upon platelet secretion; prostacyclin inhibited AGEPC-induced aggregation and secretion. EDTA or EGTA inhibited AGEPC-induced aggregation but had no effect on platelet secretion.

Original language	English (US)
Pages (from-to)	903-906
Number of pages	4
Journal	Journal of Clinical Investigation
Volume	67
Issue number	3
DOIs	https://doi.org/10.1172/JCI110108
State	Published - 1981

ASJC Scopus subject areas

General Medicine

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abstract = "Acetyl glyceryl ether phosphorylcholine (AGEPC) induced dose-dependent platelet aggregation and release of [3H]serotonin and platelet factor 4 in citrated human platelet-rich plasma. ADP scavengers or indomethacin prevented irreversible platelet aggregation responses induced by 0.2 μM AGEPC but had no effect upon platelet secretion; prostacyclin inhibited AGEPC-induced aggregation and secretion. EDTA or EGTA inhibited AGEPC-induced aggregation but had no effect on platelet secretion.",

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AU - Hanahan, D. J.

AU - Pinckard, R. N.

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AB - Acetyl glyceryl ether phosphorylcholine (AGEPC) induced dose-dependent platelet aggregation and release of [3H]serotonin and platelet factor 4 in citrated human platelet-rich plasma. ADP scavengers or indomethacin prevented irreversible platelet aggregation responses induced by 0.2 μM AGEPC but had no effect upon platelet secretion; prostacyclin inhibited AGEPC-induced aggregation and secretion. EDTA or EGTA inhibited AGEPC-induced aggregation but had no effect on platelet secretion.

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Human platelet stimulation by acetyl glyceryl ether phosphorylcholine

Abstract

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