Human platelet stimulation by acetyl glyceryl ether phosphorylcholine

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135 Scopus citations

Abstract

Acetyl glyceryl ether phosphorylcholine (AGEPC) induced dose-dependent platelet aggregation and release of [3H]serotonin and platelet factor 4 in citrated human platelet-rich plasma. ADP scavengers or indomethacin prevented irreversible platelet aggregation responses induced by 0.2 μM AGEPC but had no effect upon platelet secretion; prostacyclin inhibited AGEPC-induced aggregation and secretion. EDTA or EGTA inhibited AGEPC-induced aggregation but had no effect on platelet secretion.

Original languageEnglish (US)
Pages (from-to)903-906
Number of pages4
JournalJournal of Clinical Investigation
Volume67
Issue number3
DOIs
StatePublished - 1981

ASJC Scopus subject areas

  • Medicine(all)

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