Human parathyroid hormone gene (PTH) is on short arm of chromosome 11

S. L. Naylor, Alan Y Sakaguchi, P. Szoka, G. N. Hendy, H. M. Kronenberg, A. Rich, T. B. Shows

Research output: Contribution to journalArticle

66 Citations (Scopus)

Abstract

The human gene for parathyroid hormone (PTH) was chromosomally mapped using human-rodent hybrids and Southern filter hybridization of cell hybrid DNA. A recombinant DNA probe containing human PTH cDNA insert (pPTHm122) hybridized to a 3.7-kb fragment in human DNA cleaved with the restriction enzyme EcoRI. By correlating the presence of this fragment in somatic cell hybrid DNA with the human chromosomal content of the hybrid cells, the PTH gene was mapped to the short arm of the chromosome 11.

Original languageEnglish (US)
Pages (from-to)609-616
Number of pages8
JournalSomatic Cell Genetics
Volume9
Issue number5
DOIs
StatePublished - Sep 1983
Externally publishedYes

Fingerprint

Chromosomes, Human, Pair 11
Hybrid Cells
Genes
DNA
Recombinant DNA
DNA Probes
Parathyroid Hormone
Rodentia
Complementary DNA
human PTH protein
Enzymes

ASJC Scopus subject areas

  • Genetics
  • Medicine(all)

Cite this

Naylor, S. L., Sakaguchi, A. Y., Szoka, P., Hendy, G. N., Kronenberg, H. M., Rich, A., & Shows, T. B. (1983). Human parathyroid hormone gene (PTH) is on short arm of chromosome 11. Somatic Cell Genetics, 9(5), 609-616. https://doi.org/10.1007/BF01574261

Human parathyroid hormone gene (PTH) is on short arm of chromosome 11. / Naylor, S. L.; Sakaguchi, Alan Y; Szoka, P.; Hendy, G. N.; Kronenberg, H. M.; Rich, A.; Shows, T. B.

In: Somatic Cell Genetics, Vol. 9, No. 5, 09.1983, p. 609-616.

Research output: Contribution to journalArticle

Naylor, SL, Sakaguchi, AY, Szoka, P, Hendy, GN, Kronenberg, HM, Rich, A & Shows, TB 1983, 'Human parathyroid hormone gene (PTH) is on short arm of chromosome 11', Somatic Cell Genetics, vol. 9, no. 5, pp. 609-616. https://doi.org/10.1007/BF01574261
Naylor, S. L. ; Sakaguchi, Alan Y ; Szoka, P. ; Hendy, G. N. ; Kronenberg, H. M. ; Rich, A. ; Shows, T. B. / Human parathyroid hormone gene (PTH) is on short arm of chromosome 11. In: Somatic Cell Genetics. 1983 ; Vol. 9, No. 5. pp. 609-616.
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