Human papillomavirus-associated oral epithelial dysplasia (koilocytic dysplasia) An entity of unknown biologic potential

Maria Fornatora, Anne C Jones, Stanley Kerpel, Paul Freedman

Research output: Contribution to journalArticle

52 Citations (Scopus)

Abstract

Intraepithelial neoplasia of the female genital tract has long been associated with human papillomavirus infection. To date, there have been no previously published studies of oral dysplasia that have identified light microscopic features predictive of the presence of human papillomavirus. We identified a variant of oral epithelial dysplasia, koilocytic dysplasia, that exhibited light microscopic features suggestive of HPV infection. To determine if these microscopic features were specifically correlated with human papillomavirus infection, DNA in situ hybridization for human papillomavirus 6/11, 16/18, and 31/33/51 was performed on 31 lesions diagnosed histologically as koilocytic dysplasia. Seventeen matched control cases of conventional oral epithelial dysplasia were also analyzed for human papillomavirus. Human papillomavirus DNA was detected significantly more often (p < 0.001) in koilocytic dysplasia (80.6%) than conventional oral epithelial dysplasia (0.0%). Positive cases of koilocytic dysplasia contained either intermediate-risk (31/33/51) or high-risk (16/18) human papillomavirus types whether or not they contained low-risk human papillomavirus types (6/11). The histologic and clinical presentation of koilocytic dysplasia was unique. Lesions demonstrated koilocytes and other microscopic characteristics of human papillomavirus infection, as well as features of conventional epithelial dysplasia. A striking male predominance was noted, as was a relatively young average age of presentation (39.0 years). On the basis of our preliminary analysis, we conclude that oral koilocytic dysplasia represents a unique pathologic entity and that the presence of human papillomavirus can be predicted on light microscopy with at least 80% accuracy. The clinical significance and potential for malignant transformation of koilocytic dysplasia remain to be investigated.

Original languageEnglish (US)
Pages (from-to)47-56
Number of pages10
JournalOral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics
Volume82
Issue number1
StatePublished - 1996
Externally publishedYes

Fingerprint

Papillomavirus Infections
Human papillomavirus 11
Human papillomavirus 6
Light
Human papillomavirus 31
Human papillomavirus 18
Human papillomavirus 16
DNA
In Situ Hybridization
Microscopy
Infection
Neoplasms

ASJC Scopus subject areas

  • Dentistry(all)
  • Pathology and Forensic Medicine
  • Radiology Nuclear Medicine and imaging
  • Surgery

Cite this

Human papillomavirus-associated oral epithelial dysplasia (koilocytic dysplasia) An entity of unknown biologic potential. / Fornatora, Maria; Jones, Anne C; Kerpel, Stanley; Freedman, Paul.

In: Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics, Vol. 82, No. 1, 1996, p. 47-56.

Research output: Contribution to journalArticle

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