Human lymphotoxin and tumor necrosis factor genes: Structure, homology and chromosomal localization

Glenn E. Nedwin, Susan L. Naylor, Alan Y Sakaguchi, Douglas Smith, Julie Jarrett-Nedwin, Diane Pennica, David V. Goeddel, Patrick W. Gray

Research output: Contribution to journalArticle

392 Citations (Scopus)

Abstract

Human Tumor Necrosis Factor and Lymphotoxin are cytotoxic proteins which have similar biological activities and share 30 percent amino acid homology. The single copy genes which encode these proteins share several structural features: each gene is approximately three kilobase pairs in length and is interrupted by three introns. In addition, these genes are closely linked and have been mapped to human chromosome 6. However, only the last exons of both genes, which code for more than 80 percent of each secreted protein, are significantly homologous (56 percent).

Original languageEnglish (US)
Pages (from-to)6361-6373
Number of pages13
JournalNucleic Acids Research
Volume13
Issue number17
DOIs
StatePublished - Sep 11 1985

Fingerprint

Tumor Necrosis Factor
Lymphotoxin-alpha
Homology
Tumor Necrosis Factor-alpha
Genes
Percent
Gene
Proteins
Protein
Chromosomes, Human, Pair 6
Human Factors
Human Chromosomes
Chromosomes
Bioactivity
Introns
Chromosome
Amino Acids
Amino acids
Exons
Human

ASJC Scopus subject areas

  • Statistics, Probability and Uncertainty
  • Applied Mathematics
  • Health, Toxicology and Mutagenesis
  • Toxicology
  • Genetics(clinical)
  • Genetics

Cite this

Nedwin, G. E., Naylor, S. L., Sakaguchi, A. Y., Smith, D., Jarrett-Nedwin, J., Pennica, D., ... Gray, P. W. (1985). Human lymphotoxin and tumor necrosis factor genes: Structure, homology and chromosomal localization. Nucleic Acids Research, 13(17), 6361-6373. https://doi.org/10.1093/nar/13.17.6361

Human lymphotoxin and tumor necrosis factor genes : Structure, homology and chromosomal localization. / Nedwin, Glenn E.; Naylor, Susan L.; Sakaguchi, Alan Y; Smith, Douglas; Jarrett-Nedwin, Julie; Pennica, Diane; Goeddel, David V.; Gray, Patrick W.

In: Nucleic Acids Research, Vol. 13, No. 17, 11.09.1985, p. 6361-6373.

Research output: Contribution to journalArticle

Nedwin, GE, Naylor, SL, Sakaguchi, AY, Smith, D, Jarrett-Nedwin, J, Pennica, D, Goeddel, DV & Gray, PW 1985, 'Human lymphotoxin and tumor necrosis factor genes: Structure, homology and chromosomal localization', Nucleic Acids Research, vol. 13, no. 17, pp. 6361-6373. https://doi.org/10.1093/nar/13.17.6361
Nedwin, Glenn E. ; Naylor, Susan L. ; Sakaguchi, Alan Y ; Smith, Douglas ; Jarrett-Nedwin, Julie ; Pennica, Diane ; Goeddel, David V. ; Gray, Patrick W. / Human lymphotoxin and tumor necrosis factor genes : Structure, homology and chromosomal localization. In: Nucleic Acids Research. 1985 ; Vol. 13, No. 17. pp. 6361-6373.
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