@article{56781de72d974950b6a34930fc25172d,
title = "Human lymphotoxin and tumor necrosis factor genes: Structure, homology and chromosomal localization",
abstract = "Human Tumor Necrosis Factor and Lymphotoxin are cytotoxic proteins which have similar biological activities and share 30 percent amino acid homology. The single copy genes which encode these proteins share several structural features: each gene is approximately three kilobase pairs in length and is interrupted by three introns. In addition, these genes are closely linked and have been mapped to human chromosome 6. However, only the last exons of both genes, which code for more than 80 percent of each secreted protein, are significantly homologous (56 percent).",
author = "Nedwin, {Glenn E.} and Naylor, {Susan L.} and Sakaguchi, {Alan Y.} and Douglas Smith and Julie Jarrett-Nedwin and Diane Pennica and Goeddel, {David V.} and Gray, {Patrick W.}",
note = "Funding Information: and Figures 3 and 4. Analysis of the chromosomal localization was Initiated at Roswell Park Memorial Institute, Buffalo, New York, and we thank Dr. Thomas Shows for the human-murine somatic cell hybrids used 1n this study. We also thank Dr. Karl Heinz Grzeschik of the University of Munster for human-murine hybrids used in the regionalization to chromosome six. This research was supported by Genentech, Inc. and grants from the National Cancer Institute (to A.Y.S.) and the March of Dimes (to S.L.N.).",
year = "1985",
month = sep,
day = "11",
doi = "10.1093/nar/13.17.6361",
language = "English (US)",
volume = "13",
pages = "6361--6373",
journal = "Nucleic acids research",
issn = "0305-1048",
publisher = "Oxford University Press",
number = "17",
}