Human leukocyte antigens antibodies after lung transplantation: Primary results of the HALT study

Ramsey R. Hachem, Malek Kamoun, Marie M. Budev, Medhat Askar, Vivek N. Ahya, James C. Lee, Deborah J. Levine, Marilyn S. Pollack, Gundeep S. Dhillon, David Weill, Kenneth B. Schechtman, Lorriana E. Leard, Jeffrey A. Golden, Lee Ann Baxter-Lowe, Thalachallour Mohanakumar, Dolly B. Tyan, Roger D. Yusen

Research output: Contribution to journalArticle

11 Scopus citations

Abstract

Donor-specific antibodies (DSA) to mismatched human leukocyte antigens (HLA) are associated with worse outcomes after lung transplantation. To determine the incidence and characteristics of DSA early after lung transplantation, we conducted a prospective multicenter observational study that used standardized treatment and testing protocols. Among 119 transplant recipients, 43 (36%) developed DSA: 6 (14%) developed DSA only to class I HLA, 23 (53%) developed DSA only to class II HLA, and 14 (33%) developed DSA to both class I and class II HLA. The median DSA mean fluorescence intensity (MFI) was 3197. We identified a significant association between the Lung Allocation Score and the development of DSA (HR = 1.02, 95% CI: 1.001-1.03, P =.047) and a significant association between DSA with an MFI ≥ 3000 and acute cellular rejection (ACR) grade ≥ A2 (HR = 2.11, 95% CI: 1.04-4.27, P =.039). However, we did not detect an association between DSA and survival. We conclude that DSA occur frequently early after lung transplantation, and most target class II HLA. DSA with an MFI ≥ 3000 have a significant association with ACR. Extended follow-up is necessary to determine the impact of DSA on other important outcomes.

Original languageEnglish (US)
Pages (from-to)2285-2294
Number of pages10
JournalAmerican Journal of Transplantation
Volume18
Issue number9
DOIs
StatePublished - Sep 2018

Keywords

  • clinical research/practice
  • histocompatibility
  • lung transplantation/pulmonology
  • major histocompatibility complex (MHC)
  • monitoring: immune
  • rejection: T cell mediated (TCMR)
  • rejection: antibody-mediated (ABMR)

ASJC Scopus subject areas

  • Immunology and Allergy
  • Transplantation
  • Pharmacology (medical)

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