Human leukocyte antigen associations in basal cell carcinoma

Patricia L. Myskowski, Marilyn S. Pollack, Ethlynn Schorr, Bo Dupont, Bijan Safai

Research output: Contribution to journalArticlepeer-review

38 Scopus citations


Basal cell carcinoma is the most common form of skin cancer and is one in which both host and environmental factors are thought to play a role in its pathogenesis. For an investigation of the role of human leukocyte antigen (HLA)-associated variations in genetic susceptibility, thirty-one patients with multiple basal cell carcinomas were typed for HLA-A, B, C, and DR antigens. Patients were compared with both local and appropriate ethnic group controls. No statistically significant association with HLA-A, B, or C antigens was noted in any group. However, a significant increase in HLA-DR1 was noted in non-Irish, non-Ashkenazi patients. A tendency toward a decrease in HLA-DR3 was also noted among patients of Irish or Ashkenazi Jewish descent. The role of HLA-associated genetic factors in this form of skin cancer needs further investigation.

Original languageEnglish (US)
Pages (from-to)997-1000
Number of pages4
JournalJournal of the American Academy of Dermatology
Issue number6
StatePublished - 1985
Externally publishedYes

ASJC Scopus subject areas

  • Dermatology


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