Abstract
A significant proportion of individuals with human immunodeficiency virus (HIV) infection develop a neurological syndrome consisting of psychomotor retardation, dementia, and associated findings that was initially termed the acquired immunodeficiency syndrome (AIDS) dementia complex. This syndrome is now commonly known as HIV-associated dementia (HAD). This chapter discusses the clinical and pathological features, and pathophysiology in HIV-associated dementia, and the role of microglia in mediating neuronal injury in HIV infection.
Original language | English (US) |
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Title of host publication | Neuroglia |
Publisher | Oxford University Press |
ISBN (Print) | 9780199865024, 0195152220, 9780195152227 |
DOIs | |
State | Published - Sep 1 2013 |
Externally published | Yes |
Keywords
- AIDS
- Brain macrophages
- Hiv-associated dementia
- Microglia
- Neuronal injury
ASJC Scopus subject areas
- Neuroscience(all)
- Medicine(all)