Human Immunodeficiency Virus Infection of the Central Nervous System

Elena Ryzhova; Dennis L. Kolson; Francisco González-Scarano

doi:10.1093/acprof:oso/9780195152227.003.0040

Human Immunodeficiency Virus Infection of the Central Nervous System

Elena Ryzhova, Dennis L. Kolson, Francisco González-Scarano

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

A significant proportion of individuals with human immunodeficiency virus (HIV) infection develop a neurological syndrome consisting of psychomotor retardation, dementia, and associated findings that was initially termed the acquired immunodeficiency syndrome (AIDS) dementia complex. This syndrome is now commonly known as HIV-associated dementia (HAD). This chapter discusses the clinical and pathological features, and pathophysiology in HIV-associated dementia, and the role of microglia in mediating neuronal injury in HIV infection.

Original language	English (US)
Title of host publication	Neuroglia
Publisher	Oxford University Press
ISBN (Print)	9780199865024, 0195152220, 9780195152227
DOIs	https://doi.org/10.1093/acprof:oso/9780195152227.003.0040
State	Published - Sep 1 2013
Externally published	Yes

Keywords

AIDS
Brain macrophages
Hiv-associated dementia
Microglia
Neuronal injury

ASJC Scopus subject areas

Neuroscience(all)
Medicine(all)

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10.1093/acprof:oso/9780195152227.003.0040

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AB - A significant proportion of individuals with human immunodeficiency virus (HIV) infection develop a neurological syndrome consisting of psychomotor retardation, dementia, and associated findings that was initially termed the acquired immunodeficiency syndrome (AIDS) dementia complex. This syndrome is now commonly known as HIV-associated dementia (HAD). This chapter discusses the clinical and pathological features, and pathophysiology in HIV-associated dementia, and the role of microglia in mediating neuronal injury in HIV infection.

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KW - Neuronal injury

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Human Immunodeficiency Virus Infection of the Central Nervous System

Abstract

Keywords

ASJC Scopus subject areas

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