Human Immunodeficiency Virus Infection of the Central Nervous System

Elena Ryzhova, Dennis L. Kolson, Francisco González-Scarano

Research output: Chapter in Book/Report/Conference proceedingChapter


A significant proportion of individuals with human immunodeficiency virus (HIV) infection develop a neurological syndrome consisting of psychomotor retardation, dementia, and associated findings that was initially termed the acquired immunodeficiency syndrome (AIDS) dementia complex. This syndrome is now commonly known as HIV-associated dementia (HAD). This chapter discusses the clinical and pathological features, and pathophysiology in HIV-associated dementia, and the role of microglia in mediating neuronal injury in HIV infection.

Original languageEnglish (US)
Title of host publicationNeuroglia
PublisherOxford University Press
ISBN (Print)9780199865024, 0195152220, 9780195152227
StatePublished - Sep 1 2013
Externally publishedYes


  • AIDS
  • Brain macrophages
  • Hiv-associated dementia
  • Microglia
  • Neuronal injury

ASJC Scopus subject areas

  • Neuroscience(all)
  • Medicine(all)


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