Human immunodeficiency virus (HIV) and HIV infected cells in saliva and salivary glands of a patient with systemic lupus erythematosus

Chih-ko Yeh, P. C. Fox, Y. Goto, J. A. Austin, J. S. Brahim, C. H. Fox

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

A young woman with systemic lupus erythematosus (SLE) was infected with human immunodeficiency virus 1 (HIV-1) and about 6 years later developed persistent bilateral parotid gland enlargement. It was unclear whether this represented salivary gland involvement as a component of her SLE (secondary Sjogren's syndrome) or the initial clinical manifestation of her HIV-1 infection. HIV proviral DNA was found in individual salivary glandular secretions and in whole saliva. Additionally, cells positive for HIV RNA were isolated from whole saliva. A parotid gland biopsy revealed infiltrating lymphocytes containing large amounts of HIV RNA.

Original languageEnglish (US)
Pages (from-to)1810-1812
Number of pages3
JournalJournal of Rheumatology
Volume19
Issue number11
StatePublished - 1992
Externally publishedYes

Fingerprint

Salivary Glands
Saliva
Systemic Lupus Erythematosus
Parotid Gland
HIV
HIV-1
RNA
Sjogren's Syndrome
Virus Diseases
Lymphocytes
Biopsy
DNA

Keywords

  • HIV
  • oral
  • parotid
  • saliva
  • salivary gland
  • SLE

ASJC Scopus subject areas

  • Immunology
  • Rheumatology

Cite this

Human immunodeficiency virus (HIV) and HIV infected cells in saliva and salivary glands of a patient with systemic lupus erythematosus. / Yeh, Chih-ko; Fox, P. C.; Goto, Y.; Austin, J. A.; Brahim, J. S.; Fox, C. H.

In: Journal of Rheumatology, Vol. 19, No. 11, 1992, p. 1810-1812.

Research output: Contribution to journalArticle

Yeh, Chih-ko ; Fox, P. C. ; Goto, Y. ; Austin, J. A. ; Brahim, J. S. ; Fox, C. H. / Human immunodeficiency virus (HIV) and HIV infected cells in saliva and salivary glands of a patient with systemic lupus erythematosus. In: Journal of Rheumatology. 1992 ; Vol. 19, No. 11. pp. 1810-1812.
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