Human immunodeficiency virus (HIV) and HIV infected cells in saliva and salivary glands of a patient with systemic lupus erythematosus

C. K. Yeh, P. C. Fox, Y. Goto, J. A. Austin, J. S. Brahim, C. H. Fox

Research output: Contribution to journalArticlepeer-review

22 Scopus citations

Abstract

A young woman with systemic lupus erythematosus (SLE) was infected with human immunodeficiency virus 1 (HIV-1) and about 6 years later developed persistent bilateral parotid gland enlargement. It was unclear whether this represented salivary gland involvement as a component of her SLE (secondary Sjogren's syndrome) or the initial clinical manifestation of her HIV-1 infection. HIV proviral DNA was found in individual salivary glandular secretions and in whole saliva. Additionally, cells positive for HIV RNA were isolated from whole saliva. A parotid gland biopsy revealed infiltrating lymphocytes containing large amounts of HIV RNA.

Original languageEnglish (US)
Pages (from-to)1810-1812
Number of pages3
JournalJournal of Rheumatology
Volume19
Issue number11
StatePublished - Jan 1 1992
Externally publishedYes

Keywords

  • HIV
  • SLE
  • oral
  • parotid
  • saliva
  • salivary gland

ASJC Scopus subject areas

  • Rheumatology
  • Immunology and Allergy
  • Immunology

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