Human herpesvirus 6 and cytomegalovirus infections in children with human immunodeficiency virus infection and cancer

Charles T. Leach, Brad H. Pollock, Kenneth L. Mcclain, Richard T. Parmley, Sharon B. Murphy, Hal B. Jenson

Research output: Contribution to journalArticlepeer-review

9 Scopus citations

Abstract

Aim. Measure the prevalence of human herpesvirus 6 (HHV-6) and cytomegalovirus (CMV) infections in children and adolescents with HIV infection and malignancy. Methods. Semiquantitative polymerase chain reaction and serology were used to test for HHV-6 and CMV infections in 31 cases (HIV-infected children with cancer), 56 HIV controls (HIV-infected children without cancer) and 30 cancer controls (HIV-uninfected children with cancer). Results. In cases, HIV controls and cancer controls, HHV-6 DNA was detected in 29, 39 and 34%, respectively, and CMV DNA was detected in 13, 4 and 7%, respectively. Four cases (13%) and no HIV controls or cancer controls harbored HHV-6 subtype A (P = 0.014). In cases, HIV controls and cancer controls, the prevalence of HHV-6 antibodies was 58, 68 and 93%, respectively, and the prevalence of CMV antibodies was 71, 48 and 70%, respectively. HHV-6 seroprevalence was lower in cases than in cancer controls (P = 0.002), even with adjustments for age and CD4 concentrations; however, HHV-6 infection rates (presence of HHV-6 DNA and/or HHV-6 antibodies) were similar in all groups. Stratification showed that CMV infection was more common in younger patients (ages < 8 years) without severe immune suppression (CD4 concentration >200 cells/μl) than in HIV controls (odds ration, 10.343; 95% confidence interval, 1.65, 121.57). Geometric mean titers of serum anti-CMV antibodies, but not anti-HHV-6 antibodies, were higher in cases (1:71) than in HIV controls (1:33) (P = 0.005). Conclusions. HHV-6 and CMV infections were common among children with HIV infection and cancer. CMV seropositivity also was associated with cancer in younger HIV-infected patients who did not have severe immune suppression. HHV-6A was detected only in HIV-infected children with cancer.

Original languageEnglish (US)
Pages (from-to)125-132
Number of pages8
JournalPediatric Infectious Disease Journal
Volume21
Issue number2
DOIs
StatePublished - 2002
Externally publishedYes

Keywords

  • Acquired immunodeficiency syndrome
  • Acquired immunodeficiency syndrome-associated lymphomas
  • Adolescent
  • Child
  • Cytomegalovirus
  • Human herpesvirus 6
  • Human immunodeficiency virus
  • Neoplasms
  • Non-Hodgkin lymphoma

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Microbiology (medical)
  • Infectious Diseases

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