Human gastrin-releasing peptide gene is located on chromosome 18

S. L. Naylor, A. Y. Sakaguchi, E. Spindel, W. W. Chin

Research output: Contribution to journalArticlepeer-review

18 Scopus citations

Abstract

Gastrin-releasing peptide (GRP), a bombesin-like peptide, increases plasma levels of gastrin, pancreatic polypeptide, glucagon, gastric inhibitory peptide, and insulin. GRP is produced in large quantities by small-cell lung cancer and acts as a growth factor for these cells. To determine if chromosomal changes in small-cell lung cancer are related to the expression of GRP, we chromosomally mapped the gene using human-mouse somatic cell hybrids. Twenty hybrids, characterized for human chromosomes, were analyzed by Southern filter hybridization of DNA digested with EcoRI. Human DNA cut with EcoRI yields a major band of 6.8 kb and a minor band of 11.3 kb. The 6.8 kb band segregated concordantly with chromosome 18 and the marker peptidase A. The chromosome 3 abnormalities seen in small-cell lung cancer do not correlate with the chromosomal location of GRP, suggesting that the elevated expression of this gene may be due to mechanisms other than chromosomal rearrangement.

Original languageEnglish (US)
Pages (from-to)87-91
Number of pages5
JournalSomatic Cell and Molecular Genetics
Volume13
Issue number1
DOIs
StatePublished - Jan 1 1987

ASJC Scopus subject areas

  • Genetics
  • Cell Biology

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