Human ferritin H and L sequences lie on ten different chromosomes

John R. McGill; Susau L. Naylor; Alan Y. Sakaguchi; Charleen M. Moore; Dana Boyd; Kathleen J. Barrett; Thomas B. Shows; James W. Drysdale

doi:10.1007/BF00283053

Human ferritin H and L sequences lie on ten different chromosomes

John R. McGill
, Susau L. Naylor
, Alan Y. Sakaguchi
, Charleen M. Moore
, Dana Boyd
, Kathleen J. Barrett
, Thomas B. Shows
, James W. Drysdale

Department of Cell Systems & Anatomy

Research output: Contribution to journal › Article › peer-review

46 Scopus citations

Abstract

In humans, the H (heavy) and L (light) chains of the iron-storage protein ferritin, are derived from multigene families. We have examined the chromosomal distribution of these H and L sequences by Southern analysis of hybrid cell DNA and by chrosomal in situ hybridization. Our results show that human ferritin H genes and related sequences are found on at least seven different chromosomes while L genes and related sequences are on at least three different chromosomes. Further, we have mapped the chromosomal location of expressed genes for human H and L ferritin chains and have found an H sequence which may be a useful marker for idiopathic hemochromatosis.

Original language	English (US)
Pages (from-to)	66-72
Number of pages	7
Journal	Human Genetics
Volume	76
Issue number	1
DOIs	https://doi.org/10.1007/BF00283053
State	Published - May 1987

ASJC Scopus subject areas

Genetics
Genetics(clinical)

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title = "Human ferritin H and L sequences lie on ten different chromosomes",

abstract = "In humans, the H (heavy) and L (light) chains of the iron-storage protein ferritin, are derived from multigene families. We have examined the chromosomal distribution of these H and L sequences by Southern analysis of hybrid cell DNA and by chrosomal in situ hybridization. Our results show that human ferritin H genes and related sequences are found on at least seven different chromosomes while L genes and related sequences are on at least three different chromosomes. Further, we have mapped the chromosomal location of expressed genes for human H and L ferritin chains and have found an H sequence which may be a useful marker for idiopathic hemochromatosis.",

author = "McGill, \{John R.\} and Naylor, \{Susau L.\} and Sakaguchi, \{Alan Y.\} and Moore, \{Charleen M.\} and Dana Boyd and Barrett, \{Kathleen J.\} and Shows, \{Thomas B.\} and Drysdale, \{James W.\}",

year = "1987",

month = may,

doi = "10.1007/BF00283053",

language = "English (US)",

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T1 - Human ferritin H and L sequences lie on ten different chromosomes

AU - McGill, John R.

AU - Naylor, Susau L.

AU - Sakaguchi, Alan Y.

AU - Moore, Charleen M.

AU - Boyd, Dana

AU - Barrett, Kathleen J.

AU - Shows, Thomas B.

AU - Drysdale, James W.

PY - 1987/5

Y1 - 1987/5

N2 - In humans, the H (heavy) and L (light) chains of the iron-storage protein ferritin, are derived from multigene families. We have examined the chromosomal distribution of these H and L sequences by Southern analysis of hybrid cell DNA and by chrosomal in situ hybridization. Our results show that human ferritin H genes and related sequences are found on at least seven different chromosomes while L genes and related sequences are on at least three different chromosomes. Further, we have mapped the chromosomal location of expressed genes for human H and L ferritin chains and have found an H sequence which may be a useful marker for idiopathic hemochromatosis.

AB - In humans, the H (heavy) and L (light) chains of the iron-storage protein ferritin, are derived from multigene families. We have examined the chromosomal distribution of these H and L sequences by Southern analysis of hybrid cell DNA and by chrosomal in situ hybridization. Our results show that human ferritin H genes and related sequences are found on at least seven different chromosomes while L genes and related sequences are on at least three different chromosomes. Further, we have mapped the chromosomal location of expressed genes for human H and L ferritin chains and have found an H sequence which may be a useful marker for idiopathic hemochromatosis.

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SN - 0340-6717

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EP - 72

JO - Human Genetics

JF - Human Genetics

IS - 1

ER -

Human ferritin H and L sequences lie on ten different chromosomes

Abstract

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