Human ferritin H and L sequences lie on ten different chromosomes

John R. McGill; Susau L. Naylor; Alan Y. Sakaguchi; Charleen M. Moore; Dana Boyd; Kathleen J. Barrett; Thomas B. Shows; James W. Drysdale

doi:10.1007/BF00283053

Human ferritin H and L sequences lie on ten different chromosomes

John R. McGill, Susau L. Naylor, Alan Y. Sakaguchi, Charleen M. Moore, Dana Boyd, Kathleen J. Barrett, Thomas B. Shows, James W. Drysdale

Department of Cell Systems & Anatomy

Research output: Contribution to journal › Article › peer-review

46 Scopus citations

Abstract

In humans, the H (heavy) and L (light) chains of the iron-storage protein ferritin, are derived from multigene families. We have examined the chromosomal distribution of these H and L sequences by Southern analysis of hybrid cell DNA and by chrosomal in situ hybridization. Our results show that human ferritin H genes and related sequences are found on at least seven different chromosomes while L genes and related sequences are on at least three different chromosomes. Further, we have mapped the chromosomal location of expressed genes for human H and L ferritin chains and have found an H sequence which may be a useful marker for idiopathic hemochromatosis.

Original language	English (US)
Pages (from-to)	66-72
Number of pages	7
Journal	Human Genetics
Volume	76
Issue number	1
DOIs	https://doi.org/10.1007/BF00283053
State	Published - May 1987

ASJC Scopus subject areas

Genetics(clinical)
Genetics

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title = "Human ferritin H and L sequences lie on ten different chromosomes",

abstract = "In humans, the H (heavy) and L (light) chains of the iron-storage protein ferritin, are derived from multigene families. We have examined the chromosomal distribution of these H and L sequences by Southern analysis of hybrid cell DNA and by chrosomal in situ hybridization. Our results show that human ferritin H genes and related sequences are found on at least seven different chromosomes while L genes and related sequences are on at least three different chromosomes. Further, we have mapped the chromosomal location of expressed genes for human H and L ferritin chains and have found an H sequence which may be a useful marker for idiopathic hemochromatosis.",

author = "McGill, {John R.} and Naylor, {Susau L.} and Sakaguchi, {Alan Y.} and Moore, {Charleen M.} and Dana Boyd and Barrett, {Kathleen J.} and Shows, {Thomas B.} and Drysdale, {James W.}",

year = "1987",

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T1 - Human ferritin H and L sequences lie on ten different chromosomes

AU - McGill, John R.

AU - Naylor, Susau L.

AU - Sakaguchi, Alan Y.

AU - Moore, Charleen M.

AU - Boyd, Dana

AU - Barrett, Kathleen J.

AU - Shows, Thomas B.

AU - Drysdale, James W.

PY - 1987/5

Y1 - 1987/5

N2 - In humans, the H (heavy) and L (light) chains of the iron-storage protein ferritin, are derived from multigene families. We have examined the chromosomal distribution of these H and L sequences by Southern analysis of hybrid cell DNA and by chrosomal in situ hybridization. Our results show that human ferritin H genes and related sequences are found on at least seven different chromosomes while L genes and related sequences are on at least three different chromosomes. Further, we have mapped the chromosomal location of expressed genes for human H and L ferritin chains and have found an H sequence which may be a useful marker for idiopathic hemochromatosis.

AB - In humans, the H (heavy) and L (light) chains of the iron-storage protein ferritin, are derived from multigene families. We have examined the chromosomal distribution of these H and L sequences by Southern analysis of hybrid cell DNA and by chrosomal in situ hybridization. Our results show that human ferritin H genes and related sequences are found on at least seven different chromosomes while L genes and related sequences are on at least three different chromosomes. Further, we have mapped the chromosomal location of expressed genes for human H and L ferritin chains and have found an H sequence which may be a useful marker for idiopathic hemochromatosis.

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Human ferritin H and L sequences lie on ten different chromosomes

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