Human ferritin H and L sequences lie on ten different chromosomes

John R. McGill, Susau L. Naylor, Alan Y Sakaguchi, Charleen M. Moore, Dana Boyd, Kathleen J. Barrett, Thomas B. Shows, James W. Drysdale

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Abstract

In humans, the H (heavy) and L (light) chains of the iron-storage protein ferritin, are derived from multigene families. We have examined the chromosomal distribution of these H and L sequences by Southern analysis of hybrid cell DNA and by chrosomal in situ hybridization. Our results show that human ferritin H genes and related sequences are found on at least seven different chromosomes while L genes and related sequences are on at least three different chromosomes. Further, we have mapped the chromosomal location of expressed genes for human H and L ferritin chains and have found an H sequence which may be a useful marker for idiopathic hemochromatosis.

Original languageEnglish (US)
Pages (from-to)66-72
Number of pages7
JournalHuman Genetics
Volume76
Issue number1
DOIs
StatePublished - May 1987

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Apoferritins
Chromosomes
Genes
Hemochromatosis
Hybrid Cells
Ferritins
Multigene Family
In Situ Hybridization
Sequence Analysis
Iron
Light
DNA
Proteins

ASJC Scopus subject areas

  • Genetics(clinical)
  • Genetics

Cite this

McGill, J. R., Naylor, S. L., Sakaguchi, A. Y., Moore, C. M., Boyd, D., Barrett, K. J., ... Drysdale, J. W. (1987). Human ferritin H and L sequences lie on ten different chromosomes. Human Genetics, 76(1), 66-72. https://doi.org/10.1007/BF00283053

Human ferritin H and L sequences lie on ten different chromosomes. / McGill, John R.; Naylor, Susau L.; Sakaguchi, Alan Y; Moore, Charleen M.; Boyd, Dana; Barrett, Kathleen J.; Shows, Thomas B.; Drysdale, James W.

In: Human Genetics, Vol. 76, No. 1, 05.1987, p. 66-72.

Research output: Contribution to journalArticle

McGill, JR, Naylor, SL, Sakaguchi, AY, Moore, CM, Boyd, D, Barrett, KJ, Shows, TB & Drysdale, JW 1987, 'Human ferritin H and L sequences lie on ten different chromosomes', Human Genetics, vol. 76, no. 1, pp. 66-72. https://doi.org/10.1007/BF00283053
McGill, John R. ; Naylor, Susau L. ; Sakaguchi, Alan Y ; Moore, Charleen M. ; Boyd, Dana ; Barrett, Kathleen J. ; Shows, Thomas B. ; Drysdale, James W. / Human ferritin H and L sequences lie on ten different chromosomes. In: Human Genetics. 1987 ; Vol. 76, No. 1. pp. 66-72.
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