Human ferritin H and L sequences lie on ten different chromosomes

John R. McGill, Susau L. Naylor, Alan Y. Sakaguchi, Charleen M. Moore, Dana Boyd, Kathleen J. Barrett, Thomas B. Shows, James W. Drysdale

Research output: Contribution to journalArticlepeer-review

44 Scopus citations

Abstract

In humans, the H (heavy) and L (light) chains of the iron-storage protein ferritin, are derived from multigene families. We have examined the chromosomal distribution of these H and L sequences by Southern analysis of hybrid cell DNA and by chrosomal in situ hybridization. Our results show that human ferritin H genes and related sequences are found on at least seven different chromosomes while L genes and related sequences are on at least three different chromosomes. Further, we have mapped the chromosomal location of expressed genes for human H and L ferritin chains and have found an H sequence which may be a useful marker for idiopathic hemochromatosis.

Original languageEnglish (US)
Pages (from-to)66-72
Number of pages7
JournalHuman Genetics
Volume76
Issue number1
DOIs
StatePublished - May 1987

ASJC Scopus subject areas

  • Genetics
  • Genetics(clinical)

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