Human cytochrome P450 oxidoreductase deficiency caused by the Y181D mutation: Molecular consequences and rescue of defect

Medicine & Life Sciences

• Antley-Bixler Syndrome Phenotype 100%
• Flavin Mononucleotide 79%
• NADPH-Ferrihemoprotein Reductase 36%
• Mutation 30%
• Cytochrome P-450 CYP1A2 26%
• Membranes 12%
• 2-anthramine 11%
• 2-amino-3-methylimidazo(4,5-f)quinoline 11%
• 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone 10%
• Steroid 17-alpha-Hydroxylase 9%
• Congenital adrenal hyperplasia due to 21 hydroxylase deficiency 9%
• Flavin-Adenine Dinucleotide 9%
• Congenital Adrenal Hyperplasia 8%
• Cytochrome P-450 CYP1A1 8%
• NADP 7%
• Exons 5%
• Fluorescence 5%
• Electrons 5%

Chemical Compounds

• Flavin Mononucleotide 73%
• Cytochrome P450 57%
• Mutation 45%
• Activation Constant 32%
• Flavin Adenine Dinucleotide 8%
• Quinoline 6%
• Fluorescence Quenching 6%
• Catalyst Property 5%
• Titration 5%
• Pharmacological Metabolism 5%