Human c-Ki-ras2 proto-oncogene on chromosome 12

Alan Y. Sakaguchi, Susan L. Naylor, Thomas B. Shows, John J. Toole, Melissa McCoy, Robert A. Weinberg

Research output: Contribution to journalArticle

55 Scopus citations

Abstract

A human colonic adenocarcinoma transforming gene, recently identified as a cellular homolog of the Kirsten sarcoma gene (ν-ras), was used to assign the human cellular Kirsten ras2 gene to chromosome 12 by the Southern hybridization method. A single 640 base-pair Eco RI-Hind III fragment of the transforming gene, isolated by DNA transfection and molecular cloning, can detect a single Eco RI fragment (2.9 kilobase pairs) of DNA from phenotypically normal cells. The data suggest a constant chromosomal location of c-Ki-ras2.

Original languageEnglish (US)
Pages (from-to)1081-1083
Number of pages3
JournalScience
Volume219
Issue number4588
DOIs
StatePublished - 1983
Externally publishedYes

ASJC Scopus subject areas

  • General

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    Sakaguchi, A. Y., Naylor, S. L., Shows, T. B., Toole, J. J., McCoy, M., & Weinberg, R. A. (1983). Human c-Ki-ras2 proto-oncogene on chromosome 12. Science, 219(4588), 1081-1083. https://doi.org/10.1126/science.6823569