Human c-Ki-ras2 proto-oncogene on chromosome 12

Alan Y. Sakaguchi, Susan L. Naylor, Thomas B. Shows, John J. Toole, Melissa McCoy, Robert A. Weinberg

Research output: Contribution to journalArticlepeer-review

57 Scopus citations


A human colonic adenocarcinoma transforming gene, recently identified as a cellular homolog of the Kirsten sarcoma gene (ν-ras), was used to assign the human cellular Kirsten ras2 gene to chromosome 12 by the Southern hybridization method. A single 640 base-pair Eco RI-Hind III fragment of the transforming gene, isolated by DNA transfection and molecular cloning, can detect a single Eco RI fragment (2.9 kilobase pairs) of DNA from phenotypically normal cells. The data suggest a constant chromosomal location of c-Ki-ras2.

Original languageEnglish (US)
Pages (from-to)1081-1083
Number of pages3
Issue number4588
StatePublished - 1983
Externally publishedYes

ASJC Scopus subject areas

  • General


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