Human apolipoprotein A-I and C-III genes reside in the p11 → q13 region of chromosome 11

S. W. Law, G. Gray, H. B. Brewer, Alan Y Sakaguchi, S. L. Naylor

Research output: Contribution to journalArticle

37 Citations (Scopus)

Abstract

Apolipoprotein (apo) A-1 is a major protein of high density lipoproteins (HDL). The gene for apoA-I has been localized to the p11 → q13 region of chromosome 11 by filter hybridization analysis of mouse-human hybrid cell cDNAs containing chromosome 11 translocations utilizing a cloned human apoA-I cDNA probe. The known linkage of apoA-I and apoC-III also permitted the simultaneous assignment of the apoC-III gene to the same region on chromosome 11. Comparison with previously established gene linkages on the mouse and human genome suggests that apoA-I + apoC-III may be linked to the esterase A4 and uroporphyrinogen synthase genes which are present on the long arm of human chromosome 11. The localization of the apoA-I + apoC-III genes in the p11 → q13 region of chromosome 11 represents a definitive chromosomal assignment of a human apolipoprotein gene, and will now anable more detailed analysis of the geneomic organization and linkages of the apolipoprotein genes.

Original languageEnglish (US)
Pages (from-to)934-942
Number of pages9
JournalBiochemical and Biophysical Research Communications
Volume118
Issue number3
DOIs
StatePublished - Feb 14 1984
Externally publishedYes

Fingerprint

Apolipoproteins C
Chromosomes, Human, Pair 11
Chromosomes
Apolipoprotein A-I
Apolipoprotein C-III
Genes
Apolipoproteins
Uroporphyrinogens
Complementary DNA
Hybrid Cells
Human Chromosomes
Human Genome
Esterases
HDL Lipoproteins
human APOA1 protein

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Molecular Biology

Cite this

Human apolipoprotein A-I and C-III genes reside in the p11 → q13 region of chromosome 11. / Law, S. W.; Gray, G.; Brewer, H. B.; Sakaguchi, Alan Y; Naylor, S. L.

In: Biochemical and Biophysical Research Communications, Vol. 118, No. 3, 14.02.1984, p. 934-942.

Research output: Contribution to journalArticle

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AU - Gray, G.

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AU - Naylor, S. L.

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N2 - Apolipoprotein (apo) A-1 is a major protein of high density lipoproteins (HDL). The gene for apoA-I has been localized to the p11 → q13 region of chromosome 11 by filter hybridization analysis of mouse-human hybrid cell cDNAs containing chromosome 11 translocations utilizing a cloned human apoA-I cDNA probe. The known linkage of apoA-I and apoC-III also permitted the simultaneous assignment of the apoC-III gene to the same region on chromosome 11. Comparison with previously established gene linkages on the mouse and human genome suggests that apoA-I + apoC-III may be linked to the esterase A4 and uroporphyrinogen synthase genes which are present on the long arm of human chromosome 11. The localization of the apoA-I + apoC-III genes in the p11 → q13 region of chromosome 11 represents a definitive chromosomal assignment of a human apolipoprotein gene, and will now anable more detailed analysis of the geneomic organization and linkages of the apolipoprotein genes.

AB - Apolipoprotein (apo) A-1 is a major protein of high density lipoproteins (HDL). The gene for apoA-I has been localized to the p11 → q13 region of chromosome 11 by filter hybridization analysis of mouse-human hybrid cell cDNAs containing chromosome 11 translocations utilizing a cloned human apoA-I cDNA probe. The known linkage of apoA-I and apoC-III also permitted the simultaneous assignment of the apoC-III gene to the same region on chromosome 11. Comparison with previously established gene linkages on the mouse and human genome suggests that apoA-I + apoC-III may be linked to the esterase A4 and uroporphyrinogen synthase genes which are present on the long arm of human chromosome 11. The localization of the apoA-I + apoC-III genes in the p11 → q13 region of chromosome 11 represents a definitive chromosomal assignment of a human apolipoprotein gene, and will now anable more detailed analysis of the geneomic organization and linkages of the apolipoprotein genes.

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