Abstract
Human apolipoprotein (apo) B-100 is the major apolipoprotein of low density lipoproteins (LDL) and the principal ligand for interaction with the LDL receptor. The gene for apoB-100 has been localized to the p23 → pter region of chromosome 2 by filter hybridization analysis with radiolabelled apoB-100 cDNA probes and human-mouse somatic cell hybrids containing chromosome 2 translocations. Other genes at the end of the short arm of chromosome 2 include acid phosphatase, proopiomelanocortin complex, malate dehydrogenase, and N-myc, the latter gene has been previously localized to the same bands (2p23 → pter) as the apoB-100 gene. The localization of the apoB-100 gene to the p23 → pter region of chromosome 2 completes the genomic organizational relationship of the LDL receptor and the two apolipoprotein ligands for the LDL receptor, apoE and apoB-100; the LDL receptor and apoE having been previously localized to chromosome 19.
Original language | English (US) |
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Pages (from-to) | 1003-1012 |
Number of pages | 10 |
Journal | Biochemical and Biophysical Research Communications |
Volume | 131 |
Issue number | 2 |
DOIs | |
State | Published - Sep 16 1985 |
ASJC Scopus subject areas
- Biophysics
- Biochemistry
- Molecular Biology
- Cell Biology