Human apoB-100 gene resides in the p23 → pter region of chromosome 2

S. W. Law, N. Lee, J. C. Monge, H. B. Brewer, A. Y. Sakaguchi, S. L. Naylor

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Abstract

Human apolipoprotein (apo) B-100 is the major apolipoprotein of low density lipoproteins (LDL) and the principal ligand for interaction with the LDL receptor. The gene for apoB-100 has been localized to the p23 → pter region of chromosome 2 by filter hybridization analysis with radiolabelled apoB-100 cDNA probes and human-mouse somatic cell hybrids containing chromosome 2 translocations. Other genes at the end of the short arm of chromosome 2 include acid phosphatase, proopiomelanocortin complex, malate dehydrogenase, and N-myc, the latter gene has been previously localized to the same bands (2p23 → pter) as the apoB-100 gene. The localization of the apoB-100 gene to the p23 → pter region of chromosome 2 completes the genomic organizational relationship of the LDL receptor and the two apolipoprotein ligands for the LDL receptor, apoE and apoB-100; the LDL receptor and apoE having been previously localized to chromosome 19.

Original languageEnglish (US)
Pages (from-to)1003-1012
Number of pages10
JournalBiochemical and Biophysical Research Communications
Volume131
Issue number2
DOIs
StatePublished - Sep 16 1985

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ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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