Abstract
Human apolipoprotein (apo) B-100 is the major apolipoprotein of low density lipoproteins (LDL) and the principal ligand for interaction with the LDL receptor. The gene for apoB-100 has been localized to the p23 → pter region of chromosome 2 by filter hybridization analysis with radiolabelled apoB-100 cDNA probes and human-mouse somatic cell hybrids containing chromosome 2 translocations. Other genes at the end of the short arm of chromosome 2 include acid phosphatase, proopiomelanocortin complex, malate dehydrogenase, and N-myc, the latter gene has been previously localized to the same bands (2p23 → pter) as the apoB-100 gene. The localization of the apoB-100 gene to the p23 → pter region of chromosome 2 completes the genomic organizational relationship of the LDL receptor and the two apolipoprotein ligands for the LDL receptor, apoE and apoB-100; the LDL receptor and apoE having been previously localized to chromosome 19.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1003-1012 |
| Number of pages | 10 |
| Journal | Biochemical and Biophysical Research Communications |
| Volume | 131 |
| Issue number | 2 |
| DOIs | |
| State | Published - Sep 16 1985 |
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ASJC Scopus subject areas
- Biochemistry
- Biophysics
- Molecular Biology
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Human apoB-100 gene resides in the p23 → pter region of chromosome 2. / Law, S. W.; Lee, N.; Monge, J. C.; Brewer, H. B.; Sakaguchi, Alan Y; Naylor, S. L.
In: Biochemical and Biophysical Research Communications, Vol. 131, No. 2, 16.09.1985, p. 1003-1012.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Human apoB-100 gene resides in the p23 → pter region of chromosome 2
AU - Law, S. W.
AU - Lee, N.
AU - Monge, J. C.
AU - Brewer, H. B.
AU - Sakaguchi, Alan Y
AU - Naylor, S. L.
PY - 1985/9/16
Y1 - 1985/9/16
N2 - Human apolipoprotein (apo) B-100 is the major apolipoprotein of low density lipoproteins (LDL) and the principal ligand for interaction with the LDL receptor. The gene for apoB-100 has been localized to the p23 → pter region of chromosome 2 by filter hybridization analysis with radiolabelled apoB-100 cDNA probes and human-mouse somatic cell hybrids containing chromosome 2 translocations. Other genes at the end of the short arm of chromosome 2 include acid phosphatase, proopiomelanocortin complex, malate dehydrogenase, and N-myc, the latter gene has been previously localized to the same bands (2p23 → pter) as the apoB-100 gene. The localization of the apoB-100 gene to the p23 → pter region of chromosome 2 completes the genomic organizational relationship of the LDL receptor and the two apolipoprotein ligands for the LDL receptor, apoE and apoB-100; the LDL receptor and apoE having been previously localized to chromosome 19.
AB - Human apolipoprotein (apo) B-100 is the major apolipoprotein of low density lipoproteins (LDL) and the principal ligand for interaction with the LDL receptor. The gene for apoB-100 has been localized to the p23 → pter region of chromosome 2 by filter hybridization analysis with radiolabelled apoB-100 cDNA probes and human-mouse somatic cell hybrids containing chromosome 2 translocations. Other genes at the end of the short arm of chromosome 2 include acid phosphatase, proopiomelanocortin complex, malate dehydrogenase, and N-myc, the latter gene has been previously localized to the same bands (2p23 → pter) as the apoB-100 gene. The localization of the apoB-100 gene to the p23 → pter region of chromosome 2 completes the genomic organizational relationship of the LDL receptor and the two apolipoprotein ligands for the LDL receptor, apoE and apoB-100; the LDL receptor and apoE having been previously localized to chromosome 19.
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U2 - 10.1016/0006-291X(85)91339-7
DO - 10.1016/0006-291X(85)91339-7
M3 - Article
C2 - 3840371
AN - SCOPUS:0022408396
VL - 131
SP - 1003
EP - 1012
JO - Biochemical and Biophysical Research Communications
JF - Biochemical and Biophysical Research Communications
SN - 0006-291X
IS - 2
ER -